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Simultaneous determination of chlorine and sodium in large volume parenteral solutions by instrumental neutron activation analysis

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Abstract

Large volume parenteral solutions are pharmaceutical products containing as active compounds aminoacids, carbohydrates, calcium, chlorine, magnesium, potassium and sodium. A very simple fast and accurate method has been developed for the simultaneous determination of chlorine and sodium in large volume parenteral solutions by instrumental neutron activation analysis. Two reference materials were used for the precision and accuracy tests. The applicability of the method was checked by the assay of chlorine and sodium in large volume parenteral solutions from the Greek market. The results from all the analyzed samples showed that the proposed method with the advantages of simplicity (no chemical procedure is needed), rapidity (two-element analysis in one sample with one set of runs in 20 minutes) high precision and high accuracy is suitable for routine determinations of chlorine and sodium in large volume parenteral solutions.

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Authors and Affiliations

  1. Radioanalytical Laboratory, Institute of Physical Chemistry, Nuclear Research Center “Demokritos” Aghia Paraskevi Attikis, 153 10, Athens, (Greece)

    G. D. Kanias

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  1. G. D. Kanias
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Kanias, G.D. Simultaneous determination of chlorine and sodium in large volume parenteral solutions by instrumental neutron activation analysis. Journal of Radioanalytical and Nuclear Chemistry, Articles 116, 347–354 (1987). https://doi.org/10.1007/BF02035779

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  • DOI: https://doi.org/10.1007/BF02035779

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