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Preparation of L-asparagine complex of technetium-99m

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Abstract

Various methods were experimented to obtain complex of L-asparagine with99mTc. The VII state of Tc was reduced with direct reduction by SnCl2 and complex compound could not be obtained. For this reason, ligand exchange with99mTc-gluconate complex was tried and 20% yield was obtained.99mTc-pyrophosphate complex was carred out as second ligand exchanger and 50% yield was obtained in this experiment. Optimum conditions for ligand exchange with pyrophosphate are pH 11,50°C temperature, 60 minutes for reaction time and 278: 1 for pyrophosphate concentration to SnCl2 ratio.

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References

  1. P. Richards, W. D. Tucker, S. C. Srivastava, Int. J. Appl. Radiation Isotopes, 33 (1982) 793.

    Google Scholar 

  2. E. Deutsch, K. Libson, Comments Inorg. Chem., 3 (1984) 83.

    Google Scholar 

  3. K. H. Bremer, Radiochim. Acta, 41 (1987) 73.

    Google Scholar 

  4. P. Ünak, M. Yegane, J. Radioanal. Nucl. Chem., 201 (1995) 65.

    Google Scholar 

  5. D. A. Cooney, R. E. Handschumacher, Annu. Rev. Phamacol., 10 (1970) 421.

    Google Scholar 

  6. J. F. Keefer, A. D. A. Moraga, S. M. Schuster, Biochem. Med., 34 (1985) 135.

    PubMed  Google Scholar 

  7. S.-C.-M. Persano, Preparation of L-Asparagine Complex with Technetium. Inst. de Pesquisas Energeticas e Nucleares, Sao Paulo (Brazil), Ph. D. Thesis, 1981.

    Google Scholar 

  8. J. Legendzievics, H. Kozlowski, B. J. Trzeobiatowska, E. Huskowska, Inorg. Nucl. Chem. Lett., 15 (1979) 349.

    Google Scholar 

  9. M. K. Dewanjee, Seminars in Nuclear Medicine, Vol. 20, No. 1, Jan., 1990, p. 5.

    PubMed  Google Scholar 

  10. L. T. Mashburn, J. C. Wriston, Jr., Biochem. Biophys. Res. Commun., 12 (1963) 50.

    Google Scholar 

  11. L. T. Mashburn, J. C. Wriston, Jr., Arch. Biochem. Biophys., 105 (1964) 451.

    Google Scholar 

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Authors and Affiliations

  1. Institute of Nuclear Sciences, Ege University, Bornova, 35100, Izmir, Turkey

    F. Yurt & P. Ünak

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  1. F. Yurt
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  2. P. Ünak
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Correspondence to P. Ünak.

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Yurt, F., Ünak, P. Preparation of L-asparagine complex of technetium-99m. J Radioanal Nucl Chem 220, 121–124 (1997). https://doi.org/10.1007/BF02035362

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  • DOI: https://doi.org/10.1007/BF02035362

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