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Preparation of N-[11C]methyl-2,5-dimethoxy-4-methylamphetamine

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Abstract

In order to evaluate the neurobiological mechanism causing the psychogenic effects of N-methyl-2,5-dimethoxy-4-methylamphetamine (MDOM), the11C labelled analogue was prepared for application in in vivo PET studies by the reaction of 2,5-dimethoxy-4-methylamphetamine (DOM) with [11C]CH3I. The radiochemical yield was determined in dependence on time, temperature, solvent and amount of substrate. The best conditions for fast labelling reactions with11C on a preparative scale were found to be a reaction time of 10 miutes at 110°C using 1 mg DOM in acetonitrile thus obtaining radiochemical yields of 80% (based on produced [11C]CH3I).

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Authors and Affiliations

  1. Section Radiopharmacy, PET-Center, Tübingen, Germany

    M. Solbach, A. Blocher & H. -J. Machulla

  2. Institute of Pharmacy, Eberhardt-Karls-University Tübingen, Tübingen, Germany

    D. Gündisch & K. -A. Kovar

Authors
  1. M. Solbach
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  2. D. Gündisch
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  3. A. Blocher
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  4. K. -A. Kovar
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  5. H. -J. Machulla
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Solbach, M., Gündisch, D., Blocher, A. et al. Preparation of N-[11C]methyl-2,5-dimethoxy-4-methylamphetamine. J Radioanal Nucl Chem 220, 109–111 (1997). https://doi.org/10.1007/BF02035359

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  • DOI: https://doi.org/10.1007/BF02035359

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