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Preparation of N-[11C]methyl-2,5-dimethoxy-4-bromo-amphetamine

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Abstract

For in vivo receptor studies N-[11C]methyl-2,5-dimethoxy-4-bromo-amphetamine, [11C]MDOB, was synthesized by the reaction of [11C]CH3I with DOB in acetonitrile. The labelling yield was determined in dependence on amount of precursor, time and temperature of the methylation reaction. During 10 to 15 minutes 60% to 70% of [11C]MDOB has been obtained at 110°C.

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References

  1. A. Shulgin, A. Shulgin, PIHKAL: A Chemical Love Story, Transform Press, Berkeley, California, 1991, ISBN 0-9630096-0-5.

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Authors and Affiliations

  1. Section Radiopharmacy, PET-Center, Institute of Pharmacy, Eberhardt-Karls-University Tübingen, Tübingen, Germany

    M. Solbach, D. Gündisch, A. Blocher, K. A. Kovar & H. J. Machulla

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  1. M. Solbach
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  2. D. Gündisch
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  3. A. Blocher
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  4. K. A. Kovar
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  5. H. J. Machulla
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Solbach, M., Gündisch, D., Blocher, A. et al. Preparation of N-[11C]methyl-2,5-dimethoxy-4-bromo-amphetamine. J Radioanal Nucl Chem 221, 211–212 (1997). https://doi.org/10.1007/BF02035269

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  • DOI: https://doi.org/10.1007/BF02035269

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