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Experientia

, Volume 34, Issue 12, pp 1644–1645 | Cite as

Modulation of antibody synthesis by an anti-tumour alga

  • P. J. Neveu
  • O. Morin
  • M. Miègeville
  • B. P. Le Mevel
  • C. Vermeil
Anatomica, Histologica, Embryologica, Carcinologica

Summary

An unicellular alga,Chlorella pyrenoidosa, which had been reported to protect C3H mice against sarcoma BP8, is shown, when injected in Freund's incomplete adjuvant, to modulate the antibody synthesis induced by immunization with a hapten-carrier complex.C. pyrenoidosa appeared to be able to initiate an antigenic competition between hapten and carrier determinants of the antigen molecule during antibody synthesis, and thus it could be speculated thatC. pyrenoidosa modulates the immune response at the macrophage level.

Keywords

Immune Response Sarcoma Chlorella Unicellular Alga Antibody Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 3.
    L.J. Old, D.A. Clarke and B. Benacerraf, Nature184, 291 (1959).PubMedGoogle Scholar
  2. 4.
    B.N. Halpern, G. Biozzi, C. Stiffel and D. Mouton, Nature212, 853 (1966).PubMedGoogle Scholar
  3. 5.
    Z.T. Mankowski, I.C. Diller and M.E. Fisher, Cancer Res.17, 382 (1957).PubMedGoogle Scholar
  4. 6.
    P. Lemonde, R. Dubreuil, A. Guindon and G. Lussier, J. natl Cancer Inst.47, 1013 (1971).PubMedGoogle Scholar
  5. 7.
    C. Vermeil and O. Morin, C.r. Soc. Biol.170, 646 (1976).Google Scholar
  6. 8.
    B. Benacerraf and P.G.H. Gell, Immunology2, 53 (1959).PubMedGoogle Scholar
  7. 9.
    J.H.L. Playfair, Clin. exp. Immunol.8, 839 (1971).PubMedGoogle Scholar
  8. 10.
    B. Benacerraf and W.E. Paul, in: Cellular interactions in the immune response, p. 298. Ed. S. Cohen, G. Cudkowitz and R.T. McCluskey, Karger, Basel 1971.Google Scholar
  9. 11.
    H. Wigzell, Transplant. Rev.5, 76 (1970).PubMedGoogle Scholar
  10. 12.
    G.A. Voisin and F. Toullet, Annls Inst. Pasteur111, 376 (1976).Google Scholar
  11. 13.
    P.J. Neveu, Immunology33, 269 (1977).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • P. J. Neveu
    • 1
    • 2
  • O. Morin
    • 1
    • 2
  • M. Miègeville
    • 1
    • 2
  • B. P. Le Mevel
    • 1
    • 2
  • C. Vermeil
    • 1
    • 2
  1. 1.Formation de Recherche Associée no 13 INSERM ‘Les interactions cellulaires dans le Cancer’UER de Médecine et CRLC NantesNantes(France)
  2. 2.Laboratoire de Parasitologie UER de MédicineNantes CédexFrance

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