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Sodium-dependence of sustained force in potassium contracture of cat ventricle

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Summary

Following exposure to low-Na solution, the initial phase of K-contracture in cat ventricle is prominent while the second (sustained) phase is markedly attenuated. Monensin, a Na-specific ionophore, enhances the second phase of K-contracture following exposure to low-Na solution.

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Authors and Affiliations

  1. Department of Pharmacology, University of Miami School of Medicine, 33101, Miami, Florida, USA

    J. R. Wiggins & A. L. Bassett

  2. Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, 33612, Tampa, Florida, USA

    J. R. Wiggins & A. L. Bassett

Authors
  1. J. R. Wiggins
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  2. A. L. Bassett
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Additional information

This study is supported by NIH grant HL-19044 and a Grantin-Aid from the American Heart Association-Greater Miami Affiliate.

The authors wish to thank Ms Diane Rodman for invaluable technical assistance.

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Wiggins, J.R., Bassett, A.L. Sodium-dependence of sustained force in potassium contracture of cat ventricle. Experientia 34, 1591–1592 (1978). https://doi.org/10.1007/BF02034693

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  • DOI: https://doi.org/10.1007/BF02034693

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