Advertisement

Experientia

, Volume 34, Issue 12, pp 1585–1586 | Cite as

Endothelial injury by nicotine and its prevention

  • J. Hladovec
Physiologica

Summary

Nicotine administered i.v. or p.o. in doses above 0.0125 mg/kg to the rat caused a highly significant increase in circulating anuclear carcasses of endothelial cells estimated by an original method. This effect of nicotine was completely prevented by a prior oral administration of the flavonoids hydroxyethylrutosides (HR) or Mono-7-HR.

Keywords

Endothelial Cell Nicotine Flavonoid Oral Administration Original Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 2.
    J. Hladovec and P. Rossmann, Thrombosis Res.3, 665 (1973).Google Scholar
  2. 3.
    J. Hladovec, Arzneimittel-Forsch.27, 1073 (1977).Google Scholar

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • J. Hladovec
    • 1
  1. 1.Cardiovascular Research CentreInstitute for Clinical and Experimental MedicinePrague(Czechoslovakia)

Personalised recommendations