, Volume 34, Issue 12, pp 1585–1586 | Cite as

Endothelial injury by nicotine and its prevention

  • J. Hladovec


Nicotine administered i.v. or p.o. in doses above 0.0125 mg/kg to the rat caused a highly significant increase in circulating anuclear carcasses of endothelial cells estimated by an original method. This effect of nicotine was completely prevented by a prior oral administration of the flavonoids hydroxyethylrutosides (HR) or Mono-7-HR.


Endothelial Cell Nicotine Flavonoid Oral Administration Original Method 


  1. 2.
    J. Hladovec and P. Rossmann, Thrombosis Res.3, 665 (1973).Google Scholar
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    J. Hladovec, Arzneimittel-Forsch.27, 1073 (1977).Google Scholar

Copyright information

© Birkhäuser Verlag 1978

Authors and Affiliations

  • J. Hladovec
    • 1
  1. 1.Cardiovascular Research CentreInstitute for Clinical and Experimental MedicinePrague(Czechoslovakia)

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