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Inactivation of superoxide dismutase by several thiocarbamic acid derivatives

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  • Chimica, Biochimica
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Summary

4 thiocarbamic acid derivatives inhibited superoxide dismutase (SOD) activity in vitro. Dimethyldithiocarbamate also inhibited tissue SOD in mice in vivo. These data extend previously published results on the inhibitory action of diethyldithiocarbamate on SOD activity.

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Authors and Affiliations

  1. Department of Neurology, Mt. Sinai School of Medicine, Fifth Avenue and 100th Street, 10029, New York, New York, USA

    R. E. Heikkila, Felicitas S. Cabbat & G. Cohen

Authors
  1. R. E. Heikkila
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  2. Felicitas S. Cabbat
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  3. G. Cohen
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Additional information

Supported by the Clinical Research Center for the study of Parkinson's and Allied Diseases, Grant NS-05184 from the US Public Health Service.

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Heikkila, R.E., Cabbat, F.S. & Cohen, G. Inactivation of superoxide dismutase by several thiocarbamic acid derivatives. Experientia 34, 1553–1554 (1978). https://doi.org/10.1007/BF02034668

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  • DOI: https://doi.org/10.1007/BF02034668

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