The elemental composition of breast tissue: Can this be related to breast particle deposition?
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In vitro instrumental neutron activation analysis (INAA) has been performed, yielding a range of minor and trace elemental concentrations for 46 paired samples of surgically-excised cancer breast tissue. In addition results of the soft X-ray microradiography of excised breast specimens have been used to quantify breast-particle clustering parameters, including area of cluster and nearest neighbour distance. Significant differences between elemental composition in histologically normal tissues and tissues exhibiting malignant lesions are supported by the observation of significant differences in particle clustering parameters. These observations have led to the investigation of the possible association between elemental composition of diseased breast tissues and the formation of breast particles. In particular a scanning electron microscope (SEM) with an energy dispersive X-ray (EDX) facility has been used to locate breast particles and conduct microanalysis of the particle constiuency. Results indicate these particles to consist of a complex of Ca and other elements including Mg, P, S and the ionic salts Na, Cl and K.
KeywordsCancer Breast Elemental Composition Breast Tissue Instrumental Neutron Activation Analysis Energy Dispersive
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