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153Sm metallic-hydroxide macroaggregates: An improved preparation for radiation synovectomy

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Abstract

A new type of preparation employing153Sm metallic-hydroxide macroaggregates (153Sm-MHM) for radiation synovectomy was developed. The radiopharmaceutical was prepared by reacting the aqueous solution of153SmCl3 with sodium borohydride solution in 0.5N NaOH. Microscopic analysis showed that153Sm-MHM mean particle size was 4 μm (range 1–15 μm) avoiding the formation of fine particles (<1 μm) which were153Sm-hydroxide macroaggregates preparations (153Sm-HM). Also, suspension properties as sedimentation rate, were better for153Sm-MHM than for153Sm-hydroxyapatite and153Sm-HM. Biological studies in normal rabbits demonstrated high retention into de Knee joint space even at 48 h after administration of153Sm-MHM (>99%).

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Authors and Affiliations

  1. Department of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Km. 36.5 Carretera México-Toluca, C. P. 52045, Salazar, Edo. de México

    G. Ferro-Flores, L. García-Salinas, M. Pedraza-López, J. I. Tendilla & M. A. López-Gómez

  2. Department of Nuclear Medicine, Instituto Nacional de Pediatría, Insurgentes 3700-C Colonia Cuicuilco Insurgentes, C. P. 04330, México, D. F., México

    M. A. González-Zavala

Authors
  1. G. Ferro-Flores
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  2. L. García-Salinas
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  3. M. Pedraza-López
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  4. M. A. González-Zavala
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  5. J. I. Tendilla
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  6. M. A. López-Gómez
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Ferro-Flores, G., García-Salinas, L., Pedraza-López, M. et al. 153Sm metallic-hydroxide macroaggregates: An improved preparation for radiation synovectomy. J Radioanal Nucl Chem 222, 93–97 (1997). https://doi.org/10.1007/BF02034253

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  • DOI: https://doi.org/10.1007/BF02034253

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