Skip to main content


Log in

Primary mesenteric tumor of adult T-cell leukemia/lymphoma: Report of a case

  • Case Reports
  • Published:
Surgery Today Aims and scope Submit manuscript


A rare case of primary mesenteric tumor of adult T-cell leukemia lymphoma (ATLL) is reported. A 64-year-old man was admitted to our hospital after the diagnosis of a palpable ileocecal tumor. Although the serologic test for human T-cell lymphotrophic virus type I (HTLV-I) antibody was positive, neither ATLL cells in the peripheral blood nor systemic lymphadenopathy were observed. At laparotomy, the tumor was histopathologically revealed to be ATLL, and wasalso found to be restricted to the mesentery. An immunohistochemical examination of the tumor tissue using a specific monoclonal antibody was positive for CD2 and CD4, and negative for CD8. Proviral genome integration in the tumor cells was found by Southern blotting using a32p-labeled HTLV-1 probe withEcoRI andPstI digestion. Combination chemotherapy including cyclophosphamide, Adriamycin, vincristine, and prednisolone was begun postoperatively, but the patient did not respond to therapy. Up to now, only two cases of ATLL originating primarily in the abdominal cavity have been reported. These cases all demonstrate the need to consider the possibility of a primary ATLL mesenteric tumor without leukemic manifestation in the peripheral blood.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.


  1. Takatsuki K, Uchiyama T, Sagawa K, Yodoi J (1977) Adult T cell leukemia in Japan. In: Seno S, Takaku F, Irino S (eds) Topics in hematology. Excerpta Medica, Amsterdam, pp 73–77

    Google Scholar 

  2. Tajima K, Itoh S (1992) Epidemiology of HTLV-I (in Japanese). Virus 42:49–57

    Google Scholar 

  3. Takatsuki K, Yamaguchi K, Watanabe T, Mochizuki M, Kiyokawa T, Mori S (1992) Adult T-cell leukemia and HTLV-1 related diseases. Gann Monogr Cancer Res 39:1–15

    Google Scholar 

  4. Sakai H, Kiyotoshi S, Miyamoto R, Kataoka K, Hamazaki K, Mimura H, Orita K (1992) A case of primary mesenteric malignant lymphoma (in Japanese). Shoukaki Geka (Gastroenterological Surgery) 15:1403–1406

    Google Scholar 

  5. Utsunomiya A, Tsukasa S, Hashimoto S, Matsumoto T, Matsumoto M, Yunoki K (1983) Refractory diarrhea in a patient with adult T cell leukemia. Acta Haematol Jpn 46:1010–1015

    Google Scholar 

  6. Yamaguchi K, Yoshioka R, Kiyokawa T, Seiki M, Yoshida M, Takatsuki K (1986) Lymphoma type adult T-cell leukemia. Hematol Oncol 4:59–65

    PubMed  Google Scholar 

  7. Kubonishi I, Daibata M, Yano S, Fujishita M, Taguchi H, Miyoshi I (1987) Gastric lymphoma associated with human T-cell leukemia virus type I. Arch Intern Med 147:603–605

    PubMed  Google Scholar 

  8. Shimamoto Y, Yamaguchi M, Tokunaga O, Nagumo F, Tadano J (1991) Primary extranodal lymphoma caused by HTLV-I Br J Haematol 78:126–128

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Nishimura, Y., Takenaka, H., Yoshidome, K. et al. Primary mesenteric tumor of adult T-cell leukemia/lymphoma: Report of a case. Surg Today 24, 263–267 (1994).

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI:

Key Words