Surgery Today

, Volume 24, Issue 3, pp 210–214 | Cite as

Five-year results of a randomized clinical trial comparing modified radical mastectomy and extended radical mastectomy for stage II breast cancer

  • Tadaoki Morimoto
  • Yasumasa Monden
  • Shigemitsu Takashima
  • Sueyoshi Itoh
  • Takashi Kimura
  • Hiroyuki Yamamoto
  • Muneo Kitamura
  • Kozo Inui
  • Naoomi Tanaka
  • Takashi Nagano
  • Noriaki Fujishima
  • June Yanada
  • Masaki Tsuruno
  • Kansei Komaki
Original Articles

Abstract

A controlled cooperative study was carried out to assess the value of modified radical mastectomy for patients with stage II breast cancer. The data was analyzed from 11 institutions in the Shikoku District participating in a prospective clinical trial in which patients were randomly assigned either to a modified radical mastectomy group or an extended radical mastectomy group. These two groups of patients were similar to each other in terms of such background factors as age distribution, menopausal status, TNM classification, tumor size, location of the primary tumor, axillary nodal involvement, histological type, and estrogen receptor status. The median follow-up times in the modified and extended radical mastectomy groups were 4.7 and 4.5 years, respectively. The cumulative curves indicated no difference between the two groups in either disease-free survival or overall survival. The survival rates were classified according to the presence or absence of axillary nodal metastases. However, no significant difference was found between the two groups. These findings thus suggest that the routine removal of the grossly uninvolved major pectoral muscle and parasternal lymph nodes is not necessary in patients with stage II breast cancer.

Key Words

Breast cancer stage II randomized study modified radical mastectomy extended radical mastectomy 

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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Tadaoki Morimoto
    • 1
  • Yasumasa Monden
    • 1
  • Shigemitsu Takashima
    • 2
  • Sueyoshi Itoh
    • 3
  • Takashi Kimura
    • 4
  • Hiroyuki Yamamoto
    • 5
  • Muneo Kitamura
    • 6
  • Kozo Inui
    • 7
  • Naoomi Tanaka
    • 8
  • Takashi Nagano
    • 9
  • Noriaki Fujishima
    • 10
  • June Yanada
    • 11
  • Masaki Tsuruno
    • 12
  • Kansei Komaki
    • 1
  1. 1.The University of TokushimaTokushimaJapan
  2. 2.National Shikoku Cancer CenterMatsuyamaJapan
  3. 3.Itoh Breast Surgery ClinicKochiJapan
  4. 4.Ehime Prefectural Center HospitalMatsuyamaJapan
  5. 5.Kochi City HospitalKochiJapan
  6. 6.Hosogi HospitalKochiJapan
  7. 7.Anann Central Hospital of The Medical AssociationAnannJapan
  8. 8.Tokushima Municipal HospitalTokushimaJapan
  9. 9.Tokushima Prefectural Central HospitalTokushimaJapan
  10. 10.Kochi Red Cross HospitalKochiJapan
  11. 11.Health Insurance Naruto HospitalNarutoJapan
  12. 12.Kagawa Rousai HospitalMarugameJapan

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