Summary
We observed a sibship of two children who had the syndrome of early-onset pauciarticular arthritis with anti-nuclear antibodies; their paternal grandmother died of progressive systemic sclerosis. Since the early-onset pauciarticular syndrome is very rare or non-existent in adults, the findings in this kindred pair raise the possibility that this disorder and adult systemic sclerosis may share some genetic or other etiological factors.
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Lewkonia, R.M., Bowen, T.J. Familial concurrence of pauciarticular syndrome and systemic sclerosis. Clin Rheumatol 5, 252–255 (1986). https://doi.org/10.1007/BF02032365
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DOI: https://doi.org/10.1007/BF02032365