Summary
The hormonal variations in postmenopausal osteoporosis are not precisely defined. The duration of the menopause and other factors, such as the weight of the patients, may be of significance. Having a basic criterion of uniformi ty in weight, sixty postmenopausal women were studied in regard to the following aspects: urinary hydroxyproline, estrone, estradiol, parathyroid hormone, thyrox ine, triiodothyronine, thyroid stimulating hormone, cortisol and metacarpal cortical area/total area. They were divided into: Group A: 15 patients with osteoporosis and five years since menopause; Group B: 15 patients without osteoporosis (age matched with group A); Group C: 15 patients with osteoporosis and more than ten years since menopause; and Group D: 15 patients without osteoporosis (age matched with Group C). In the group with postmenopausal osteoporosis (A and C) there is a significant increase in urinary hydroxyproline/creatinine and a significant decrease of the cortical area/total area when we compared them with age-matched groups. The hormonal values do not vary significantly among the four groups. Ours results indicate an increase of bone resorption as a cause of postmenopausal osteoporosis. The hormonal variations, if any, cannot be related to basal values.
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References
Riggs, B.L. Hormonal factors in the pathogenesis of postmenopausal osteoporosis. In: Barzel US. Osteoporosis II. New York, Grune & Stratton, 1979, 111.
Avioli, L.V. The endoctrinology of involutional osteoporosis. In: Osteoporosis: Recent advances in pathogenesis and treatment. DeLuca H.F., Frost, H.M., Jee, W.S.S., Johnston, C., Parfitt, A.M. Baltimore, University Park Press, 1980, 343.
Johnston, C., Epstein, S. The endocrinology of osteoporosis. In: Endocrinology of calcium metabolism. Parson JA. New York, Raven Press, 1982, 467.
Albright, F., Reifenstein, E.C. Parathyroid glands and metabolic bone disease. Baltimore Williams and Wilkins, 1948.
Taggart, H.M., Chesnut, C.H., Ivey, J.L., Baylink, D.J., Sisom, K., Huber, M.B., Roos, B.A. Deficient calcitonin response to calcium stimulation in postmenopausal osteoporosis? Lancet, 1982, 2, 475–477.
Rico, H., Del Rio, A., Vila, T., Patino, R., Carrera, F., Espinos D. The role of growth hormone in the pathogenesis of postmenopausal osteoporosis. Arch Intern Med, 1979, 139, 1263–1265.
Avioli, L.V., Baran, D.T., Whyte, M.P., Teiltebaum, S. The biochemical and skeletal heterogeneity of postmenopausal osteoporosis. In: Barzel US: Osteoporosis II. New York, Grune & Stratton. 1979, 49.
Meunier, P.J., Coupron, P., Edouard, C., Alexandre, C., Bressot, C., Lips, P., Boyce B.F. Bone histomorphometry in osteoporotic states. In: Barzel US. Osteoporosis II. New York, Grune & Stratton, 1979, 27.
Meema, H.E., Bunker, M.L., Meema, S. Loss of compact bone due to menopause. Obstet Gynecol, 1965, 26, 333–343.
Aitken, J.M., Hart, D.M., Anderson, J.B., Lindsay, R., Smith, D.A., Speirs, C.T. Osteoporosis after oöphorectomy for non-malignant disease in premenopausal women. Br J Med, 1973, 2, 325–328.
Horsman, A., Simpson, M., Kirby, D.A., Nordin, B.E.C. Non-linear bone loss in oophorectomized women. Br J Radiol, 1977, 50, 504–507.
Chakravarti, S., Collins, W.P., Forescat, J.D., Newton, J.R., Oram, D.H., Studd, J.W.W. Hormonal profiles after the menopause. Br Med J, 1976, 2, 78–786.
Saville, P.D., Nilsson, B.E.R. Height and weight in symptomatic postmenopausal osteoporosis. Clin Orthop, 1966, 45, 49–57.
Lindquist, C., Bengtsson, C., Hansson, T., Roos, B. Bone mineral content in relation to age and menopause in middle-aged women. Scand J Clin Lab Invest, 1981, 41, 215–223.
Davidson, S.J., Ross, R.K., Paganini-Hill, A., Hammond, G.D., Sliteri, P.K., Judd, H.L. Total and free estrogens and androgens in postmenopausal women with hip fratures. J Clin Endocrinol Metab, 1982, 54, 115–120.
Horsman, A., Simpson, B. The measurement of sequential changes in cortical bone geometry. Br J Radiol, 1975, 48, 471–476.
Rico Lenza, H., Del Rio Vàzquez, A., Lozano Tonkin, C., Cigüenza Gabriel, R., Espinos Perez. Paràmetros de masa òsea en la poblaciòn normal española. Rev Clin Esp, 1978, 148, 475–478.
Prockop, D.J., Udenfriend, S. A specific method for the analysis of hydroxyproline in tissue and urine. Anal Biochem, 1960, 1, 228–239.
Tausky, H.H. A microcolorometric determination of creatinine in urine by the Jaffe reaction. J Biol Chem, 1954, 208, 853–856.
Wu, C.H., Lundy, L.E. Radioimmunoassay of plasma estrogens. Steroids, 1971, 18, 91–111.
Dull, T.A., Henneman, P.H. Urinary hydroxyproline as an index of colagen turnover in bone. N Engl J Med, 1963, 268, 132–134.
Powles, T.J., Leese, C.L., Bondy, P.K. Hydroxyproline excretion in patients with breast cancer and response to treatment. Br Med J, 1975, 2, 164–166.
Nordin, B.E.C. Diagnostic procedures in disorders of calcium metabolism, Din Endocrinol, 1978, 8, 55–67.
Delmas, P.D., Stenner, D., Wahner, H.W., Mann, K.G., Riggs, B.L. Serum bone GLA protein increases with aging in normal women: Implications for age-related bone loss. Calcif Tissue Int, 1982, [Suppl], 34, S4.
Nordin, B.E.C., Aaron, J., Speed, R., Crilly, R.G., Bone formation and resorption as the determinants of trabecular bone volume in postmenopausal osteoporosis. Lancet, 1981, 8, 277–279.
Lafferty, F.W., Spencer, G.E., Perason, O.H. Effects of androgens, estrogens and high calcium intakes on bone formation and resorption in osteoporosis. Am J Med, 1964, 36, 515–528.
Harris, W.H., Heaney, R.P. Skeletal renewal and metabolic bone disease. N Eng J Med, 1969, 280, 193–202.
Joly, R., Chapuy, M.C., Alexandre, C.L., Meunier, P.J. Osteoporoses a haut niveau de remodelage et fonction parathyroidienne. Pathol Biol, 1980, 7, 417–424.
Delmas, P., Wehner, H.W., Mann, K., Riggs, L.B. Assessment of bone turnover in postmenopausal osteoporosis by measurement of serum bone Glaprotein. J Lab Clin Med, 1983, 102, 470–476.
Marshall, D.H., Nordion, B.E.C. The prevention of postmenopausal bone loss. Curr Med Res Opin, 1977, 4, 73–82.
Riggs, B.L., Ryan, R.J., Wahner, H.W., Jiang, N.S., Mattox, V.R. Serum concentrations of estrogens testosterone, and gonadotropins in osteoporotic and nonosteoporotic women. J Clin Endocrinol Metab, 1973, 36, 1097–1099.
Schindler, A.E., Eberg, A., Freidrick, E. Conversion of androstenodione to estrone by human fat tissue. J Clin Endocrinol Metab, 1972, 35, 627–630.
Mac Donald, P.C., Edman, C.D., Hemsell, D.C., Porter, J.C., Siiteri, P.R. Effect of obesity on conversion of plasma androstenodione to estrone in postmenopausal women with and without endometrial cancer. Am J Obstet Gynecol, 1978, 130, 448–450.
Jasani, C., Nordion, B.E.C., Smith, D.A., Swason, I. Spinal osteoporosis and the menopause. Proc R Soc med, 1965, 58, 441–444.
Katz, F.H., Kappas, A. Influence of estradiol and estriol on urinary excretion of hydroxyproline in man. J Lab Clin Med, 1968, 71, 65–7.
Teitelbaum, J.L., Rosenberg, F.M., Richardson, C.A., Avioli, L.V. Histological studies of bone from normocalcemic postmenopausal osteoporosis patients with increased circulating parathyroid hormone. J Clin Endocrinol Metab, 1976, 42, 537–543.
Fujita, T., Orimo, H., Okano, K., Yoshikawa, M., Shino, R., Inoue, T., Itami, Y. Radioimmuno-assay of serum parathyroid hormone in postmenopausal osteoporosis. Endocrinol Jpn, 1972, 19, 571–577.
Riggs, B.L., Arnaud, C.D., Jowsey, J., Goldsmith. R.S., Kelly, P.J. Parathyroid function in primary osteoporosis. J Clin Invest, 1973, 52, 181–184.
Gallagher, J.C., Riggs, B.L., Jerpak, C.M. Arnaud, C.D. The effect of age on serum immu noreactive parathyroid hormone in normal and osteoporotic women. J Lab Clin Med, 1980, 95, 373 385.
Berlyne, G.M., Ben-Ari, J., Kusmelevsky, A. Idekman, D., Galinski, M., Hirsch, R., Shainkin, R., Yagil, R., Zlotnik, M. The etiology of senile osteoporosis: Secondary hyperparathyroidism due to renal failure. Q J Med, 1975, 44, 505–513.
Roof, B.S., Piel, C.E., Hansen, J. Serum parathyroid hormone levels and serum calcium levels from birth to senescence. Mech Ageing Dev, 1976, 5, 289–304.
Wiske, P.S., Epstein, S., Bell, N.H., Queener, S.T., Edmonson, J., Johnston, C.C. Increase in immunoreactive parathyroid hormone with age. N Eng J Med, 1979, 300, 1419–1421.
Bouillon, R., Geusens, P., Dequeker, J., De Moor, P. Parathyroid function in primary osteoporosis. Clin Sci, 1979, 57, 167–171.
Stevenson, J.C., Abeyasera, G., Hillyard, C.J., et al. Regulation of calcium-regulating hormones by exogenous sex steroids in early postmenopause. Eur J Clin Invest, 1983, 13, 481–487.
Whyte, M.P., Bergfeld, B.A., Murphy, W.A., Avioli, L.V., Teitelbaum, S.L. Postmenopausal osteoporosis: a heterogenous disorder as assessed by histomorphometric analysis of iliac crest bone from untreated patients. Am J Med, 1982, 72, 193–202.
Riggs, B.L., Jowsey, J., Kelly, P.J., Arnaud, C.D. Role of hormonal factors in the pathogenesis of postmenopausal osteoporosis. Isr J Med Sci, 1976, 12, 615–619.
Cushing, H. The basophil adenomas of the pituitary body and their clinical manifestation (Pituitary Basophilism). Bull Johns Hopkins Hosp, 1932, 50, 137–195.
Krane, S.M., Goldring, S.R. Skeletal System; neuromuscular system; emotion and mentation. In: Werner SC, Ingbar SH (ed). The thyroid. New York, Harper & Rows, 1978, 727.
Manolagas, S.C., Anderson, D.C., Lidsay, R. Adrenal steroids and the development of osteoporosis in oophorectomised women. Lancet, 1979, 2, 597–600.
Aloia, J.F., Vaswani, A., Yeh, J.K., Cohn, S.H. The pathogenesis of postmenopausal osteoporosis. Calcif Tissue Int, 1982, 34 (suppl), 28S.
Hahn, T.J. Corticosteroid-induced osteopenia. Arch Inter Med, 1978, 138, 882–885.
Caniggia, A., Gennari, C., Bianchi, V., Guideri, R. Intestinal absorption of47Ca in senile osteoporosis. Acta Med Scand, 1963, 173, 613–617.
Fucik, R.F., Kukreja, S.C., Hargis, G.K., Bowser, F.N., Henderson, W.J., Williams, G.A. Effect of glucocorticoids on function of te parathyroid glands in man. J Clin Endocrinol Metab, 1975, 40, 152–155.
Jowsey, J., Riggs, B.L. Bone formation in hypercortisolism. Acta Endocrinol, 1970, 63, 21–28.
Bouillon, R., De Moor, P., Parathyroid function in patients with hyper or hypothyroidism. J Clin Endocrinol Metab, 1974, 38, 999–1004.
Adams, P.H., Jowsey, J. Bone and mineral metabolism in hyperthyroidism: an experimental study. Endocrinology, 1967, 81, 735–740.
Rico, H., Cabranes, J.A., Almoguera, L., Millan, V., Olivares, C. Alteraciones oseas en los hipertiroidismos: sugerencia de un mecanismo inducido por la T3. Rev Iberam Invest Clin, 1982, 1, 91–97.
Rico, H., Cabranes, J.A., Paniagua, M.C. et al. Es la fosfodiesterasa la responsable de las alteraciones óseas en las disfunctiones tiroideas? Med Clin (Barc), 1983, 81, 702–704.
Castro, J.H., Genusth, S.M., Klein, L. Comparative response to parathyroid hormone in hyperthyroidism and hypothyroidism. J Clin Endocrinol Metab, 1975, 42, 839–848.
Green, M. Ageing and disease. Clin Endocrinol Metab, 1981, 10, 207–228.
Davidson, B.J., Riggs, B.L., Coulan, C.B., Toft, D.O. Concentration of cytosolic estrogen receptors in patients with postmenopausal osteoporosis. Am J Obstet Gynecol, 1980, 136, 430–434.
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Rico, H., Charro, A., Depablos, I. et al. Lack of hormonal changes in postmenopausal women of equal weight with and without osteoporosis, including relation to time of menopause. Clin Rheumatol 3, 337–343 (1984). https://doi.org/10.1007/BF02032340
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DOI: https://doi.org/10.1007/BF02032340