Clinical Rheumatology

, Volume 4, Issue 2, pp 183–188 | Cite as

Gold: Hepatotoxic and cholestatic reactions

  • A. S. Hanissian
  • B. M. Rothschild
  • S. Kaplan


Gold hepatotoxicity is an uncommon but significant clinical problem. Hepatitis was first manifested one day to four weeks after the last dose of gold at a cumulative range of 35 to 2900 mg. An interesting dichotomy was noted between cholestatic and hepatotoxic reactions. Hepatotoxic reactions were associated with other clinical signs of hyper-sensitivity, thus facilitating differential diagnosis from viral hepatitis. Sudden clinical improvement in a patient receiving gold should stimulate evaluation for a hepatotoxic reaction.

Key words

Gold Rheumatoid Arthritis Juvenile Rheumatoid Arthritis Hepatotoxiciy 


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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • A. S. Hanissian
    • 1
    • 2
  • B. M. Rothschild
    • 1
    • 2
  • S. Kaplan
    • 1
    • 2
  1. 1.Baptist Memorial Hospital-EastUniversity of Tennessee Department of Medicine and Menorah Medical CenterUSA
  2. 2.Kansas University School of MedicineKansas CityUSA

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