Clinical Rheumatology

, Volume 2, Issue 2, pp 139–143 | Cite as

A controlled study of the exocrine pancreatic function in Sjögren's syndrome and rheumatoid arthritis

  • C. Gobelet
  • J. C. Gerster
  • G. Rappoport
  • C. A. Hiroz
  • E. Maeder


The exocrine pancreatic function has been estimated using the N-benzoyl-L-Tyrosyl para-amino-benzoic acid test (NBT PABA test) and by measuring the trypsinemia by radio-immunoassay (RIA trypsinemia) in nonselected cases of Sjögren's syndrome (SS) and seropositive rheumatoid arthritis (RA) in comparison with normal controls. The NBT PABA test was pathological in 37,5% of SS and 35% of RA patients but in none of the controls. The RIA trypsinemia was found to be high in 6,2% of SS and 45% of RA patients. These findings suggest that exocrine pancreatic function is impaired in some SS and RA cases. However, this exocrine pancreatic defect was clinically silent in all patients.

Key words

Sjögren's Syndrome Rheumatoid Arthritis Exocrine Pancreatic Function NBT PABA Test 


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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • C. Gobelet
    • 1
    • 2
  • J. C. Gerster
    • 1
    • 2
  • G. Rappoport
    • 1
    • 2
  • C. A. Hiroz
    • 1
    • 2
  • E. Maeder
    • 1
    • 2
  1. 1.Rheumatology and Rehabilitation CentreCentre Hospitaliser Universitaire Vaudois (CHUV)LausanneSwitzerland
  2. 2.Biochemical Department and Ophthalmologic ClinicCentre Hospitaliser Universitaire Vaudois (CHUV)LausanneSwitzerland

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