Clinical Rheumatology

, Volume 2, Issue 2, pp 139–143 | Cite as

A controlled study of the exocrine pancreatic function in Sjögren's syndrome and rheumatoid arthritis

  • C. Gobelet
  • J. C. Gerster
  • G. Rappoport
  • C. A. Hiroz
  • E. Maeder
Originals

Summary

The exocrine pancreatic function has been estimated using the N-benzoyl-L-Tyrosyl para-amino-benzoic acid test (NBT PABA test) and by measuring the trypsinemia by radio-immunoassay (RIA trypsinemia) in nonselected cases of Sjögren's syndrome (SS) and seropositive rheumatoid arthritis (RA) in comparison with normal controls. The NBT PABA test was pathological in 37,5% of SS and 35% of RA patients but in none of the controls. The RIA trypsinemia was found to be high in 6,2% of SS and 45% of RA patients. These findings suggest that exocrine pancreatic function is impaired in some SS and RA cases. However, this exocrine pancreatic defect was clinically silent in all patients.

Key words

Sjögren's Syndrome Rheumatoid Arthritis Exocrine Pancreatic Function NBT PABA Test 

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References

  1. 1.
    Fenster, L.F., Buchanan, W.W., Laster, M., Bunim, J.J. Studies of pancreatic function in Sjögren's syndrome. Ann. Intern. Med. 1964, 61, 498–508.PubMedGoogle Scholar
  2. 2.
    Hradsky, M., Bartos, V., Keller, O. Pancreatic function in Sjögren's syndrome. Gastroenterologia 1967, 108, 252–260.PubMedGoogle Scholar
  3. 3.
    Bounameaux, Y., Gyr, K. Evaluation of the Bentiromide test as a diagnostic aid for exocrine pancreas insufficiency. Roche Internal Report. May 5th. 1980, p. 3 - Ed. by Roche.Google Scholar
  4. 4.
    Bounameaux, T., Ribet, A. Evaluation of the Bentiromide test as a diagnostic aid for exocrine pancreas insufficiency. Roche Internal Report. July 10th. 1980, p. 3 - Ed. by Roche.Google Scholar
  5. 5.
    Gobelet, C., Bambule, J., Felber, J.P., Magnenat, P. Taux de trypsine RIA dans la pancreatite chronique (résultats préliminaires). Schweiz, med. Wschr. 1978, 108, 1902–1904.Google Scholar
  6. 6.
    Zittoun, R., Diebold, J., De Carbonniere, C., Danchot, J., Zittoun, J., Eyquem, A., Schuhmann, C., Bielski-Pasquier, G. Méthode de diagnostic du syndrome de Sjögren. Sem. Hop. Paris, 1978, 54, 1021–1025.PubMedGoogle Scholar
  7. 7.
    Hermans, P., Hausler, R., Vischer, T. Diagnostic différentiel entre syndrome de Gougerot-Sjögren et sialadénose par la scintigraphie quantitative des glandes salivaires. Rev. Rhum. 1977, 44, 99–103.PubMedGoogle Scholar
  8. 8.
    Carone, F.A., Liebow, A.A. Acute pancreatic lesions in patients treated with ACTH and adrenal corticoids. N. Eng. J. Med. 1957, 257, 690.Google Scholar
  9. 9.
    Temler, R., Felber, J.P. Radioimmuno-assay of enzymes of exocrine pancreas. Biochem. Biophys. 1971, 236, 78–83.Google Scholar
  10. 10.
    Kendall, M.J. The influence of age on the Xylose Absorption Test. Gut 1970, 11, 498.PubMedGoogle Scholar
  11. 11.
    Lang, C., Gyr, K., Borer, P., Kayasseh, L., Stalder, G.A. Die Prüfung der exokrinen Pankreas funktion mit oral verabreichter N-Benzoyl-L-Tyrosyl Paraaminobenzoesäure, NBT PABA test. Schweiz. med. Wschr. 1980, 110, 522–528.PubMedGoogle Scholar
  12. 12.
    Harada, H., Mishima, K., Shundo, T., Yamamoto, N., Sasaki, T., Hinofuji, T., Hayaski, T., Ushida, Y., Kimura, I. Exocrine pancreatic function test by a synthetic peptide: Am. J. Gastroenterol. 1979, 71 (1), 45–52.PubMedGoogle Scholar
  13. 13.
    Imamura, K., Nakamura, T., Miyazava, T., Abe, Y., Kobayaski, M., Takebe, K., Toyota, T. Oral administration of chymotrypsin labile peptide for a new test of exocrine pancreatic function (PFT) in comparison with pancreozymin — secretin test. Am. J. Gastroenterol. 1978, 69 (5), 572–578.PubMedGoogle Scholar
  14. 14.
    Gyr, N.E. First experience with the new pancreatic function test in man. Curr. Probl. Clin. Biochem 1975, 5, 92–112.Google Scholar
  15. 15.
    Mitchell, C.J., Humphrey, C.S., Bullen, A.W., Kelleher, J. The diagnostic value of the oral pancreatic function test. Scand. J. Gastroenterol 1979, 14 (2), 183–187.PubMedGoogle Scholar
  16. 16.
    Arvanitakis, S., Arvanitakis, C., Greenberger, N.J. Diagnosis of exocrine pancreatic insufficiency in cystic fibrosis (CF) by a synthetic peptide (Bz-Ty-PABA) Pediatr. Res. 1977, 11, 441.Google Scholar
  17. 17.
    Sacher, M., Kobsa, A., Schmerling, D.H. PABA screening test for exocrine pancreatic function in infants and children. Arch. Dis. Child. 1978, 53, 639–641.PubMedGoogle Scholar
  18. 18.
    Malis, F., Fric, P., Kasafirek, E., Slaby, J. Functionnal examination of the pancreatic secretion with 4 (N-acetyl-L-Tyrosyl) aminobenzoic acid. Acta Hepatogastroenterol. (Stuttg) 1978, 25, 233–237.Google Scholar
  19. 19.
    Rau, R. Leberbefunde beim Sjögren-Sydrom. Schweiz Rundschau med. 1967, 66, 1437–1441.Google Scholar
  20. 20.
    Szanto, L., Farkas, K., Gyulai, E. On Sjögren's disease. Arthritis Rheum. 1957, 13, 60.Google Scholar
  21. 21.
    Ludwig, H., Schernthaner, G., Sherak, O., Kolarz, G. Antibodies to pancreatic duct cells in Sjögren's Syndrome and Rheumatoid Arthritis, Gut, 1977, 18, 311–315.PubMedGoogle Scholar
  22. 22.
    Thal, A., Murray, M.J., Egner, W. Isoantibody formation in chronic pancreatic disease. Lancet 1959, 1, 1128.PubMedGoogle Scholar
  23. 23.
    Metzger, R.S. Immunological studies on the nature of pancreas specific isoantigens. Fed. Proc. 1963, 22, 498.Google Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • C. Gobelet
    • 1
    • 2
  • J. C. Gerster
    • 1
    • 2
  • G. Rappoport
    • 1
    • 2
  • C. A. Hiroz
    • 1
    • 2
  • E. Maeder
    • 1
    • 2
  1. 1.Rheumatology and Rehabilitation CentreCentre Hospitaliser Universitaire Vaudois (CHUV)LausanneSwitzerland
  2. 2.Biochemical Department and Ophthalmologic ClinicCentre Hospitaliser Universitaire Vaudois (CHUV)LausanneSwitzerland

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