Summary
The relationship between joint fluid leukocytosis and some clinical and laboratory parameters (disease duration, ESR, maximal titres of rheumatoid factor and of antinuclear factors, blood leukocytosis and sex) was studied in 27 consecutive patients with seropositive rheumatoid arthritis. The concentration of leukocytes was significantly higher in the synovial fluid than in peripheral blood. Variations of joint fluid leukocytosis could, however, not be explained by disease duration, actual ESR, maximal rheumatoid factor or antinuclear factor titres, concentration of blood leukocytes, or sex. It is suggested that a possible correlation between joint fluid leukocytosis and the listed parameters of rheumatoid arthritis may be too complex for analysis by a linear multiple regression model in samples of the present size.
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References
Hollander, J.L., McCarty, D.J., Astorga, G., Castro-Murillo, E. Studies on the pathogenesis of rheumatoid joint inflammation. I. The ”R.A. cell” and a working hypothesis. Ann. Intern. Med. 1965, 62, 271–280.
Ropes, M.W., Bennet G.A., Cobb, S., Jacox, R., Jessor, R.A. Diagnostic criteria for rheumatoid arthritis, 1958 revision. Ann. Rheum. Dis. 1959, 18, 49–53.
Siegel, S. Nonparametric statistics for the behavioral sciences. New York, McGraw-Hill, 1956.
Snedecor, G.W., Cochran, W.G. Statistical methods. Ames: Iowa State University Press, 1967.
Bjelle, A., Norberg, B., Sjögren, G. The cytology of joint exudates in rheumatoid arthritis. Morphology and preparation techniques. Scand. J. Rheumatol. 1982, 11, 124–128.
Bäck, O., Bandmann, U., Norberg, B., Söderström, U.-B. Direct chemotaxis and leucocyteinduced chemotaxis of polymorphonuclear leucocytes. Significance of complement, incubation time and chemotactic parameters in filter chamber assays. Scand. J. Haematol. 1978, 20, 108–116.
Rydgren, L., Simmingsköld, G., Bandmann, U., Norberg, B. The role of cytoplasmic microtubules in polymorphonuclear leukocyte chemotaxis. Evidence for the release hypothesis by means of timelapse analysis of PMN movement relative to dotlike attractants. Exp. Cell Res. 1976, 99, 207–220.
Rydgren, L., Norberg, B., Svensson, B., Simmingsköld, G. The phagocytosis-associated chemotaxis of human mononuclear leucocytes from peripheral blood is not antitubulin-sensitive. Scand. J. Immunol. 1978, 7, 251–257.
Simmingsköld, G., Bandmann, U., Norberg, B. Mononuclear leucocyte chemotaxis in Boyden chambers: Inhibition by subantimitotic concentrations of antitubulins. Scand. J. Immunol. 1978, 7, 233–238.
Söderström, U.-B., Simmingsköld, G., Norberg, B., Bäck, O., Rydgren, L. Analysis of polymorphonuclear leukocytte (PMN) migration by the leading-front technique. Random locomotion and chemotaxis. Exp. Cell Res. 1979, 121, 325–329.
Bandmann, U., Norberg, B., Simmingsköld, G. Griseofulvin inhibition of polymorphonuclear leucocyte chemotaxis in Boyden chambers. Scand. J. Haematol. 1975, 15, 81–87.
Nilsson, F., Norberg, B., Frederiksen, B., Eriksson, S. The role of the MA-sensitive leukocyte chemotaxis in rheumatoid arthritis. A randomized double-blind clinical trial of griseofulvin treatment. Scand. J. Rheumatol. 1983, 12, in press.
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Norberg, B., Bjelle, A. & Eriksson, S. Joint fluid leukocytosis of patient with rheumatoid arthritis computer analysis of possible explanative factors. Clin Rheumatol 2, 53–56 (1983). https://doi.org/10.1007/BF02032068
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DOI: https://doi.org/10.1007/BF02032068