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Danazol induced pancreatitis and hepatitis

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Summary

Danazol, a C17 alkylated anabolic steroid, has been tried as a hormonomodulator in the management of systemic lupus erythematosus. We report the case of a patient receiving 400 mg of danazol per day who developed mild pancreatitis associated with hepatitis, both induced by danazol.

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References

  1. Madanes, A.E., Farber, M. Danazol. Ann Intern Med 1982, 96, 625–30.

    PubMed  Google Scholar 

  2. Spooner, S.B. Classification of side-effects of danazol therapy. J Intern Med Res 1977, 5 (suppl. 3), 15.

    Google Scholar 

  3. Dougados, M., Job-Deslandre, C., Amor, B., Menkes, C.J. Danazol therapy in systemic lupus erythematosus: a one-year prospective controlled trial on 40 female patients. J Clin Trials 1987, 24, 19–20.

    Google Scholar 

  4. Agnello, V., Gell, S., Pariser, K. Preliminary observation on danazol therapy of systemic lupus disseminated effects on DNA antibodies, thrombocytopenia and complement. J Rheumatol 1983, 10, 682–7.

    PubMed  Google Scholar 

  5. Pearson, K., Zimmermann, S.H. Danazol and liver damage. Lancet 1980, 2, 645–6.

    Article  Google Scholar 

  6. Cicardi, M., Bergamaschini, P., Tucci, A. Agostini, A., Tornaghi, C. Morphologic evaluation of the liver in hereditary angioedema patients on long-term treatment with androgen derivatives. Allergy Clin Immunol, 1972, 3, 294–7.

    Google Scholar 

  7. Stricker, B.H., Sparstesa, P. Drug-induced hepatotoxic injury. Amsterdam: Elsevier Published Sciences, 1985.

    Google Scholar 

  8. Rettenmaier, H., Pancreas. Eds: De Viegler, M., Holmes, J.H., Dratochwill, A., Kazner, E., Kraus, R., Kossof, G., Poulol, J., Strandness, D.E. In: Handbook of Clinical Ultrasound. New-York: John Willey and Sons, 1978, 335–43.

    Google Scholar 

  9. Mallory, A., Kern, F. Drug-induced pancreatitis: a critical review. Gastroenterology 1980, 78, 813–20.

    PubMed  Google Scholar 

  10. Reynolds, J.C., Inman, R., Kimberg, R.P., Chuong, S.H., Kovacs, J.E., Walsh, M.B. Acute pancreatitis in systemic lupus disseminated. Report of twenty cases and a review of the literature. Medicine (Baltimore) 1982, 61, 25–33.

    Google Scholar 

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Chevalier, X., Awada, H., Baetz, A. et al. Danazol induced pancreatitis and hepatitis. Clin Rheumatol 9, 239–241 (1990). https://doi.org/10.1007/BF02031976

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  • DOI: https://doi.org/10.1007/BF02031976

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