Skip to main content

Advertisement

SpringerLink
Log in

Increased plasma fibronectin in patients with systemic lupus erythematosus

  • Originals
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Summary

To add to our knowledge of collagen diseases, plasma fibronectin (FN) in patients with systemic lupus erythematosus (SLE) has been measured, and it was determined that the plasma FN value in those with SLE was 454±36 μg/ml, is significantly higher than the FN value in normal subjects (234±21 μg/ml. Further, the plasma FN value of patients with active SLE was significantly higher (591±46 μg/ml than that of patients with non-active SLE (287±31 μg/ml. The plasma FN value of SLE patients was also seen to be associated with the peripheral blood platelet count and with the dose level of the corticosteroid hormone administered to patients. In active SLE patients, it was similarly found that the plasma FN value had a significant correlation with the peripheral blood lymphocyte count and with the dose level of the corticosteroid hormone given to patients. Since the plasma FN value is known to be high in untreated SLE patients, it was felt that the increase of the FN value in SLE patients is not due to the effect of the corticosteroid but to the disease itself.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mosseson, M.W., Amrani, D.L. The structure and biologic activities of plasma fibronectin. Blood 1980, 56, 145–158.

    PubMed  Google Scholar 

  2. Mosher, D.F. Cross-linking of cold-insoluble globulin by fibrin stabilizing factor. J Biol Chem 1975, 250, 6614–6621.

    PubMed  CAS  Google Scholar 

  3. Clark, R.A.F., Dvorak, H.F., Colvin, R.B. Fibronectin in delayed-type hypersensitivity skin reactions. Associations with vessel permeability and endothelial cell activation. J Immunol 1981, 126, 787–793.

    PubMed  CAS  Google Scholar 

  4. Kono, I., Sakurai, T., Kabashima, T., Yamane, K., Kashiwagi, H. Fibronectin binds to C1q possible mechanisms for their coprecipitation in cryoglobulin from patients with systemic lupus erythematosus. Clin Exp Immunol 1983, 52, 305–310.

    PubMed  CAS  Google Scholar 

  5. Pommier, C.G., Inada, S., Fries, L.F., Takahashi, T., Frank, M.M., Brown, E.J. Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes. J Exp Med 1983, 157, 1844–1854.

    Article  PubMed  CAS  Google Scholar 

  6. Hayashi, M., Yamada, K.M. Divalent cation modulation of fibronectin binding to heparin and to DNA. J Biol Chem 1982, 257, 5263–5267.

    PubMed  CAS  Google Scholar 

  7. Blumenstock, F., Weber, P., Saba, T.M. Isolation and biochemical characterization of α-2-opsonic glycoprotein from rat serum. J Biol Chem 1977, 252, 7156–7162.

    PubMed  CAS  Google Scholar 

  8. Saba, T.M., Jaffe, E. Plasma fibronectin (opsonic glycoprotein); Its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function. Am J Med 1980, 68, 577–597.

    Article  PubMed  CAS  Google Scholar 

  9. Saba, T.M., Albert, W.H., Blumenstock, F.A., Evanega, G., Staehler, F., Cho, E. Evaluation of a rapid immunoturbidimetric assay for opsonic fibronectin in surgical and trauma patients. J Lab Clin Med 1981, 96, 482–491.

    Google Scholar 

  10. Kawamura, K., Tanaka, M. Kamiyama, F., Higashino, K., Kishimoto, S. Enzyme immunoassay of human plasma fibronectin in malignant collagen and liver disease. Clin Chim Acta 1982, 131, 101–108.

    Google Scholar 

  11. Eriksen, H.O., Clemmensen, I., Hansen, M.S., Ibsen, K.K. Plasma fibronectin concentration in normal subjects. Scand J Clin Lab Invest 1982, 42, 291–295.

    Article  PubMed  CAS  Google Scholar 

  12. Labat, R.J., Potazman, J.P., Deruette, J.C., Robert, L. Age-dependent increase of human plasma fibronectin. Cell Biol Int Rep 1981, 5, 969–973.

    Article  PubMed  Google Scholar 

  13. Schmidt, M.E., Dougias, S.D. Disappearance and recovery of human monocyte IgG receptor activity after phagocytosis. J Immunol 1972, 109, 914–917.

    PubMed  CAS  Google Scholar 

  14. Haakenstad, A.O., Mannik, M. Saturation of the reticuloendothelial system with soluble immune complexes. J Immunol 1974, 112, 1939–1948.

    PubMed  CAS  Google Scholar 

  15. Owen, M.R., Cimino, C.D. Synthesis of fibronectin by the isolated perfused rat liver. Blood, 1980, 59, 1305–1309.

    Google Scholar 

  16. Alitulo, K., Hovi, T., Vaber, A. Fibronectin is produced by human macrophage. J Exp Med 1980, 151, 602–613.

    Article  PubMed  Google Scholar 

  17. Cseh, K., Jakab, L., Torok, J., Kalabay, L., Marticsek, J., Pozsonyi, T., Benedek, S. Fibronectin on the surface of human lymphocytes. Immunol Lett 1985, 9, 301–305.

    PubMed  CAS  Google Scholar 

  18. Ginsberg, M.H., Painter, R.G., Forsyth, J., Birdwell, C. Thrombin increases expression of fibronectin antigen of the platelet surface. Proc Natl Acad Sci USA, 1980, 77, 1049–1053.

    PubMed  CAS  Google Scholar 

  19. Parris, T.N., Kimberly, R.P., Inman, R.P., McDougal, J.S., Gibofsky, A., Christian, C.L. Defective Fc receptor-mediated function of the mono-nuclear phagocyte system in lupus nephritis. Ann Intern Med 1982, 97, 526–532.

    PubMed  CAS  Google Scholar 

  20. Frank, M.M., Hamburger, M.I., Lawley, T.L., Kimberly, R.P., Plotz, P.H. Defective reticulo-endothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med 1979, 300, 518–523.

    Article  PubMed  CAS  Google Scholar 

  21. Lien, Y.H., Wong, M.J., Golbus, M.S., Stern, R. Hydrocortisone stimulates fibronectin synthesis in cultured fibroblasts. J Cell Physiol 1984, 120, 103–107.

    Article  PubMed  CAS  Google Scholar 

  22. Stecher, V.J., Connolly, K.M., Snyder, B.W. The effect of glucocorticoids on plasma fibronectin levels in normal and arthritic rats. Proc Soc Exp Biol Med 1986, 182, 301–307.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. First Department of Medicine, Nihon University, School of Medicine, Itabashi ku, Tokyo, Japan

    S. Nishinarita, M. Yamamoto, T. Takizawa, J. Hayakawa, M. Karasaki & S. Sawada

Authors
  1. S. Nishinarita
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Takizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. Hayakawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Karasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Sawada
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nishinarita, S., Yamamoto, M., Takizawa, T. et al. Increased plasma fibronectin in patients with systemic lupus erythematosus. Clin Rheumatol 9, 214–219 (1990). https://doi.org/10.1007/BF02031971

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02031971

Key words

Search

Navigation