Summary
In rat studies, fibronectin (Fn), a ubiquitous glycoprotein, is a T-cell mitogen and stimulates the production of interleukin 1 by peritoneal exudate macrophages. In contrast, Fn has no mitogenic activity for human lymphocytes and does not stimulate interleukin 1 release by human peripheral blood mononuclear cells. Fn increases in vitro peripheral blood mononuclear cell phytohemagglutinin responses in normals and patients with active, but not inactive, rheumatoid arthritis. Fn may alter local immunoregulation and play an active role in the rheumatoid synovial lesion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
D'Ardenne, A.J., McGee, J.O'D. Fibronectin in disease. J Pathol 1984, 142, 235–251.
Laviettes, B.B., Carsons, S., Diamond, H.S., Laskin, R.S. Synthesis, secretion, and deposition of fibronectin in cultured human synovium. Arthritis Rheum 1985, 28, 1016–1026.
Sorvillo, J.M., Pearlstein, E., C1q, a subunit of the first component of complement, enhances binding of plasma fibronectin to bacteria. Infect Immunol 1985, 49, 664–669.
Cseh, K., Jakab, L., Torok, J., Kalabay, L., Marticsek, J., Pozsonyi, T., Benedek, S. Fibronectin on the surface of human lymphocytes. Immunol Letters 1984, 9, 301–305.
Mossesson, M.W. The role of fibronectin in monocyte/macrophage function. In: Myelofibrosis and the Biology of Connective Tissue. Editors: Berk, P.D., Castro-Malaspina, H., Wasserman, L.R., N.Y., Alan, R. Liss, Inc. 1984, 155–175.
Vercellotti, G.M., McCarthy, J.B., Lindholm, P., Peterson, P.K., Jacob, H.S., Furcht, L.T. Extracellular matrix proteins (fibronectin, laminin, and type IV collagen) bind and aggregate bacteria. Am J Pathol 1985, 120, 13–21.
Yamada, K.M., Olden, K. Fibronectins-adhesive glycoproteins of cell surface and blood. Nature 1978, 275, 179–184.
Martin, B.M., Gimbrone, M.A.Jr., Majeau, G.R., Unanue, E.R., Cotran, R.S. Stimulation of human monocyte/macrophage-derived growth factor (MDGF) production by plasma fibronectin. Am J Pathol 1983, 111, 367–373.
Norris, D.A., Clark, R.A.F., Swigart, L.M., Huff, J.C., Weston, W.L., Howell, S.E. Fibronectin fragment(s) are chemotactic for human peripheral blood monocytes. J Immunol 1982, 129, 1612–1618.
Clark, R.A.F., Dvorak, H.F., Colvin, R.B. Fibronectin in delayed-type hypersensitivity reactions: Associations with vessel permeability and endothelial cell activation. J Immunol 1981, 126, 787–793.
Scott, D.L., Wainwright, A.C., Walton, K.W., Williamson, N. Significance of fibronectin in rheumatoid arthritis and osteoarthritis. Ann Rheum Dis 1981, 40, 142–153.
Shiozawa, K., Shiozawa, S., Shimizu, S., Fujita, T. Fibronectin on the surface of articular cartilage in rheumatoid arthritis. Arthritis Rheum 1984, 27, 615–622.
Shiozawa, S., Ziff, M. Immunoelectron microscopic demonstration of fibronectin in rheumatoid pannus and at the cartilage-pannus junction. Ann Rheum Dis 1983, 42, 254–263.
Beaulieu, A.D., Valet, J.P., Strevey, J. The influence of fibronectin on cryoprecipitate formation in rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum 1981, 24, 1383–1388.
Wall, R.T., Cooper, S.L., Kosek, J.C. The influence of exogenous fibronectin on blood granulocyte adherence to vascular endothelium in vitro. Exp Cell Res 1982, 140, 105–109.
Klareskog, L., Forsum, U., Scheynius, A., Kabelitz, D., Wigzell, H. Evidence in support of a self-perpetuating HLA-DR dependent delayed-type cell reaction in rheumatoid arthritis. Proc Natl Acad Sci USA 1982, 79, 3632–3636.
Lause, D.B., Beezhold, D.H., Doran, J.E. Induction of lymphocyte blast transformation by purified fibronectin in vitro. J Immunol 1984, 132, 1294–1299.
Beezhold, D.H., Lause, D.B. Stimulation of rat macrophage interleukin 1 secretion by plasma fibronectin. Immunol Invest 1987, 16, 437–442.
Lause, D., Beezhold, D. Regulation of lymphocyte reactivity by plasma fibronectin: Cellular requirements. Immunol Invest 1985, 14, 299–314.
Ryboski, J.A., Reese, M.C., Lause, D.B., Reese, A.C. Effect of fibronectin on antigen induced proliferation of Ga. J Science 1985, 43, 115–123.
Ropes, M.W., Bennet, G.A., Cobb, S., Jacox, R., Jessar, R.A. 1958 revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis 1958, 9, 175–176.
Pinals, R.S., Masi, A.F., Larsen, R.A. Special article: Preliminary criteria for clinical remission in RA. Arthritis Rheum 1981, 24, 1308–1315.
Sigal, L.H., Steere, A.C., Freeman, D.H., Dwyer, J.M. Proliferative responses of mononuclear cells in Lyme disease: Reactivity to Borrelia burgdorferi antigens is greater in joint fluid than blood. Arthritis Rheum 1986, 29, 761–768.
Alitalo, K., Hovi, T., Vaheri, A. Fibronectin is produced by human macrophages. J Exp Med 1980, 151, 602–613.
Rosenwasser, L.J., Dinarello, C.A. Ability of human leukocytic pyrogen to enhance phytohemagglutinin induced murine thymocyte proliferation. Cell Immunol 1981, 63, 134–143.
Sigal, L.H., Johnston, S.L., Phillips, P.E. Cellular immune responses to cartilage components in rheumatoid arthritis and osteoarthritis: A review and report of a study. Clin Exp Rheumatol 1988, 6, 59–66.
Seitz, M., Deimann, W., Gram, N., Hunstein, W., Gemsa, D. Characterization of blood mononuclear cells of rheumatoid arthritis patients I. Depressed lymphocyte proliferation and enhanced prostanoid release from monocytes. Clin Immunol Immunopathol 1982, 25, 405–415.
Abdou, N.I., Lindsley, H.B., Racela, L.S., Pascual, E., Hassanein, K.M. Suppressor T cell dysfunction and anti-suppressor cell antibody in active early rheumatoid arthritis. J Rheumatol 1981, 8, 9–17.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sigal, L.H. Modulatory effects of fibronectin on in vitro lymphocyte responses. Clin Rheumatol 9, 204–209 (1990). https://doi.org/10.1007/BF02031969
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02031969