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Possibilities for the immunotherapy of rheumatoid arthritis

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References

  1. Van Boxel, J.A., Paget, S.A. Predominantly T-cell infiltrate in rheumatoid synovial membranes. N Engl J Med 1975, 293, 517–520.

    Article  PubMed  Google Scholar 

  2. Klareskog, L., Forsum, U., Scheynius, A., Kablitz, D., Wigzell, H. Evidence in support of a self-perpetuating HLA-DR-dependent dalayed-type cell reaction in rheumatoid arthritis. Proc Natl Acad Sci 1982, 79, 3632–3636.

    Article  PubMed  CAS  Google Scholar 

  3. Holoshitz, J., Drucker, I., Yaretzky, A., van Eden, W., Klajman, A., Lapidot, Z., Frenkel, A., Cohen, I.R. T lymphocytes of rheumatoid arthritis patients show augmented reactivity to a fraction of mycobacteria cross-reactive with cartilage. Lancet 1986, ii, 305–309.

    Article  Google Scholar 

  4. Res, P.C., Breedveld, F.C., van Embden, J.D.A., Schaar, C.G., van Eden, W., Cohen, I.R., de Vries, R.R.P. Synovial fluid T-cell reactivity against 65 kD heat shock protein of mycobacteria in early chronic arthritis. Lancet 1988, ii, 478–480.

    Article  Google Scholar 

  5. Londei, M., Savill, C.M., Verhoef, A., Brennan, F., Leeck, Z.A., Duance, V., Maini, R.U., Feldman, M. Persistence of collagen type II- specific T-cell clones in the synovial membrane of a patient with rheumatoid arthritis. Proc Natl Acad Sci USA 1989, 86, 636–640.

    Article  PubMed  CAS  Google Scholar 

  6. Bottazzo, G.F., Pujol-Borrell, R., Hanafusa, T., Feldmann, M. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 1983, ii, 1115–1118.

    Article  Google Scholar 

  7. Burmester, G.R., Jahn, B., Gramatzki, M., Zacher, J., Kalden, J.R. Activated T-cells in vivo and in vitro: divergence in expression of Tac and Ia antigens in the nonblastoid small T-cells of inflammation and normal T-cells activated in vitro. J Immunol 1984, 133, 1230–1234.

    PubMed  CAS  Google Scholar 

  8. Teyton, L., Lotteau, V., Turmel, P., Arenzana-Seisdedos, F., Virelizier, J.L., Pujol, J.P., Loyau, G., Piatier-Tonneau, D., Auffray, C., Charron, D.J. HLA-DR, DQ and DP antigen expression in rheumatoid synovial cells: a biochemical and quantitative study. J Immunol 1987, 138, 1730–1738.

    PubMed  CAS  Google Scholar 

  9. Savill, C.M., Delves, P.J., Kioussis, D., Walker, P., Lydyard, P.M., Colaco, B., Shipley, M., Roitt I.M. A minority of patients with rheumatoid arthritis show a dominant rearrangement of T-cell receptor β chain genes in synovial lymphocytes. Scand J Immunol 1987, 25, 629–635.

    Article  PubMed  CAS  Google Scholar 

  10. Stamenkovic, I., Stegagno, M., Wright, K.A., Krane, S.M., Amento, E.P., Colvin, R.B., Duquesnoy, R.J., Kurnick, J.T. Clonal dominance among T-lymphocyte infiltrates in arthritis. Proc Natl Acad Sci 1988, 85, 1179–1183.

    Article  PubMed  CAS  Google Scholar 

  11. Paulus, H.E., Mackleder, H.I., Levine, S., Yu, D.T.Y., Macdonald, N.S. Lymphocyte involvement in rheumatoid arthritis studies during thoracic duct drainage. Arthritis Rheum 1977, 20, 1249–1262.

    Article  PubMed  CAS  Google Scholar 

  12. Karsh, J., Klippel, S.H., Plotz, P.H., Decker, J.L., Wright, D.R., Flye, M.W. Lymphapheresis in rheumatoid arthritis: a randomized trial. Arthritis Rheum 1981, 24, 867–873.

    Article  PubMed  CAS  Google Scholar 

  13. Brahn, E., Helfgott, S.M., Belli, J.A., Anderson, R.J., Reinherz, E.L., Schlossman, S.F., Austen, K.F., Trentham, D.E. Total lymphoid irradation therapy of refractory rheumatoid arthritis: Fifteen to forty-month follow-up. Arthritis Rheum 1984, 27, 481–488.

    Article  PubMed  CAS  Google Scholar 

  14. Shmerling, R.H., Trentham, D.E. Effect of antithymocyte globuline on refractory rheumatoid arthritis. Arthritis Rheum 1989, 32 (suppl) R7.

    Google Scholar 

  15. Acha Orbea, H., Mitchell, D.J., Timmermann, L. Limited heterogeneity of T-cell receptors from lymphocytes mediating antoimmune encephalomyelitis allows specific immune intervention. Cell Journal 1988, 54, 263–273.

    Article  CAS  Google Scholar 

  16. Steinman, L., Rosenbaum, J.T., Sriram, S., McDevitt, H.O. In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis. Proc Natl Acad Sci 1981, 78, 7111–7114.

    Article  PubMed  CAS  Google Scholar 

  17. Cohen, I.R., Weiner, H.L. T-cell vaccination. Immunology Today 1988, 9, 332–335.

    Article  PubMed  CAS  Google Scholar 

  18. Lider, O., Karin, N., Shinitsky, M., Cohen, I.R. Therapeutic vaccination against adjuvant arthritis using autoimmune T-cells treated with hydrostatic pressure. Proc Natl Acad Sci 1987, 84, 4577–4580.

    Article  PubMed  CAS  Google Scholar 

  19. De Vries, R.R.P. In: Immunopathogenetic mechanisms of arthritis. Eds: Goodacre, J.A., Carson Dick, W. Lancaster, MTP Press 1988, pp. 51–68.

    Google Scholar 

  20. Feldmann, M. et al. Analysis of T cell clones in rheumatoid arthritis. Springer Semin Immunopathol 1988, 10, 157–167.

    Article  PubMed  CAS  Google Scholar 

  21. Van Vollenhoven, R.F., Nagler-Anderson, C., Soriano, A. et al. Tolerance induction by a poorly arthritogenic collagen 11 can prevent collagen-induced arthritis. Cellular Immunology 1988, 115, 146–155.

    Article  PubMed  Google Scholar 

  22. Burmester, G.R., Jahn, B., Rohwer, P., Zachter, J., Winchester, R.J., Kalden, J.R. Differential expression of la antigens by rheumatoid synovial lining cells. J Clin Invest 1987, 80, 595–604.

    Article  PubMed  CAS  Google Scholar 

  23. Jonker, M., van Lambalgen, R., Mitchell, D.J., Durham, S.K., Steinman, L. Succesful treatment of EAE in rhesus monkeys with MHC class II specific monoclonal antibodies. J Autoimmunity 1988, 1, 399–414.

    Article  CAS  Google Scholar 

  24. Combe, B., Cosso, B., Clot, J., Bonneau, M., Sany, J. Human placenta-eluted gammaglobulins in immunomodulating treatment of rheumatoid arthritis. Am J Med 1985, 78, 920–928.

    Article  PubMed  CAS  Google Scholar 

  25. López-Bote, J.P., Bernabeau, C., Marquet, A., Fernandez, J.M., Larraga, V. Adjuvant-induced polyarthritis. Synovial cell activation prior to polyarthritis onset. Arthritis Rheum 1988, 31, 769–775.

    Article  PubMed  Google Scholar 

  26. Buchan, G., Barrett, K., Fujita, T., Taniguchi, T., Maini, R., Feldmann, M. Detection of activated T-cell products in the rheumatoid joint using cDNA probes to interleukin-2 (IL-2) IL-2 receptor and IFN. Clin Exp Immunol 1988, 71, 295–301.

    PubMed  CAS  Google Scholar 

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Breedveld, F.C., De Vries, R.R.P. Possibilities for the immunotherapy of rheumatoid arthritis. Clin Rheumatol 9, 171–175 (1990). https://doi.org/10.1007/BF02031964

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