Advertisement

Clinical Rheumatology

, Volume 3, Issue 4, pp 443–449 | Cite as

Infectious involvements in males with Reiter's syndrome

  • A. H. Vilppula
  • K. M. -L. Granfors
  • U. I. Yli-Kerttula
Originals

Summary

To obtain data on infectious involvements contributing to joint attacks in Reiter's syndrome (RS) 72 consecutive males with RS were investigated. Controls were 219 personally interviewed males. A history of some type of oronaso-pharyngeal or pulmonary infectious involvements were reported as often in the patients as in the controls, but the frequency of persons with a history of joint manifestations followed by these infections was significantly higher in the patients (23/72) than in the controls (8/219) (p<0.0001). Gastrointestinal involvements occurred only in a minority of cases as a triggering infection. Histories of prostatitis, gonorrhoea, condylomata acuminata, haematuria and trichomonas vaginalis infections were significantly more common in patients than in controls (p < 0.001 − p < 0.025). This finding, as well as evidence of chlamydial infection in 61%, speaks in favour of the importance of sexually transmitted diseases as an etiologic agent. A case report of triggering infections during the course of RS is given and the possible role of these infections in the immunopathogenesis in RS is discussed.

Key words

Reiter's Syndrome Chlamydia Trachomatis Yersinia 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Olhagen, B. Postinfective or reactive arthritis. Scand J Rheumatol, 1980, 9, 193–202.PubMedCrossRefGoogle Scholar
  2. 2.
    Amor, B., Laoussadi, S. Physiopathologie du syndrome de Fiessinger-Leroy-Reiter et affections apparentées. I. Rev Rhum, 1982, 49, 553–558.PubMedGoogle Scholar
  3. 3.
    Sairanen, E., Paronen, I., Mähönen, H. Reiter's syndrome: A follow-up study. Acta Med Scand, 1969, 185, 57–63.PubMedCrossRefGoogle Scholar
  4. 4.
    Csonka, C.W. Long-term follow-up and prognosis of Reiter's syndrome. Ann Rheum Dis, (suppl) 1979, 38, 24–28.CrossRefGoogle Scholar
  5. 5.
    Calin, A., Fox, R., Gerber, R.C., Gibson, D.J. Prognosis and natural history of Reiter's syndrome. Ann Rheum Dis, (suppl) 1979, 38, 29–31.CrossRefGoogle Scholar
  6. 6.
    Amor, B. Reiter's syndrome: long-term follow-up data. Ann Rheum Dis, (suppl) 1979, 38, 32–33.CrossRefGoogle Scholar
  7. 7.
    Vilppula, A.H., Yli-Kerttula, U.I., Selander, K.K., Terho, P.E. Urogenital involvements in female sexual partners of males with Reiter's syndrome. Clin Rheumatol, 1983, 2, 339–345.PubMedCrossRefGoogle Scholar
  8. 8.
    Granfors, K. Measurement of immunoglobulin M (IgM), IgG and IgA antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: persistence of serum antibodies during disease. J Clin Microbiol, 1979, 9, 336–341.PubMedGoogle Scholar
  9. 9.
    Vilppula, A.H., Yli-Kerttula, U.I., Terho, P.E. Reiter's syndrome in the population. Scand J Rheumatol, 1982, 11, 150–154.PubMedCrossRefGoogle Scholar
  10. 10.
    Leirisalo M. Rheumatic fever. Ann Clin Res, (suppl. 20) 1977, 9, 1–72.Google Scholar
  11. 11.
    Kousa, M. Clinical observations on Reiter's disease with special reference to the venereal and non-venereal aetiology. Acta Derm Venereol, (Suppl)(Stockh) 1978, 58, 1–36.Google Scholar
  12. 12.
    Friis, Reiter's disease with childhood onset having special reference to HLA B27. Scand J Rheumatol, 1980, 9, 250–252.PubMedCrossRefGoogle Scholar
  13. 13.
    Amor, B., Laoussadi, S. Physiopathologie du syndrome de Fiessinger-Leroy-Reiter et affections apparentées. II. Rev Rhum, 1982, 49, 653–658.PubMedGoogle Scholar
  14. 14.
    Schachter, J., Dawson, C.R. Human chlamydial infections. Littleton, Massachusetts, PSG Publishing Company, 1978.Google Scholar
  15. 15.
    Leino, R. Human yersiniosis. A clinical study with special reference to lymphocyte transformation in Yersinia arthritis. Academic dissertation, University of Turku, Turku Finland 1982.Google Scholar
  16. 16.
    Hahn, H., Kaufmann, S.H.E. The role of cellmediated immunity in bacterial infections. Rev Infect Dis, 1981, 3, 1221–1250.PubMedGoogle Scholar
  17. 17.
    Leino, R., Vuento, R., Koskimies, S., Viander, M., Toivanen, A. Depressed lymphocyte transformation by Yersinia and E. coli in Yersinia arthritis. Ann Rheum Dis, 1983, 42, 176–181.PubMedCrossRefGoogle Scholar
  18. 18.
    Vuento, R., Leino, R., Viander, M., Toivanen, A. In vitro lymphoproliferative response to Yersinia: depressed response in arthritic patients years after Yersinia infection. Clin Exp Rheum, 1983, 1, 219–224.Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • A. H. Vilppula
    • 1
  • K. M. -L. Granfors
    • 2
  • U. I. Yli-Kerttula
    • 1
  1. 1.Department of MedicineTampere University HospitalTampere
  2. 2.Department of Medical MicrobiologyUniversity of TurkuTurkuFinland

Personalised recommendations