Clinical Rheumatology

, Volume 5, Issue 1, pp 56–61 | Cite as

A double-blind study on the effect of discontinuation of gold therapy in patients with rheumatoid arthritis

  • H. Van Der Leeden
  • B. A. C. Dijkmans
  • J. Hermans
  • A. Cats
Originals

Summary

To assess the benefit of further gold treatment of rheumatoid arthritis (RA) patients who had already received more than 6 g of this metal, 24 such patients were included in a double-blind trial. Besides this “gold group” comprising 11 patients who received gold (Auromyose®) in the same dosage schedule as before the study, the trial included a “placebo group” comprising 13 patients who received gold in a suspension diluted 1/100. In either group clinical, laboratory, and radiological data did not differ after 6 and 24 months in relation to the results at entry except for the serum gold concentrations, which were lower in the placebo group. We conclude that discontinuation of the treatment in RA patients who have received more than 6 g gold is not harmful to the patients for at least two years after withdrawal.

Key words

Chrysotherapy Serum Concentrations Controlled Study 

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References

  1. 1.
    Ellman, P., Lawrence, J.S., Thorold, G.P. Gold therapy in rheumatoid arthritis. Br Med J 1940, 2, 314–316.Google Scholar
  2. 2.
    Fraser, T.N. Gold treatment in rheumatoid arthritis. Ann Rheum Dis 1945, 4, 71–75.Google Scholar
  3. 3.
    Sigler, J.W., Bluhm, G.B., Duncan, H., Sharp, J.T., Ensign, D.C., McCrum, W.R. Gold salts in the treatment of rheumatoid arthritis: a doubleblind study. Ann Intern Med 1974, 80, 21–26.PubMedGoogle Scholar
  4. 4.
    Gottlieb, N.L. Gold compounds in the rheumatic diseases. Eds: Kelley, W.H., Harris, jr., E.D., Ruddy, S., Sledge, C.B. In: Textbook of Rheumatology, W.B. Saunders Company, Philadelphia 1981, 796–814.Google Scholar
  5. 5.
    Van de Stadt, R.J., Abbo-Tilstra, B. Gold binding to blood cells and serum proteins during chrysotherapy. Ann Rheum Dis 1980, 39, 31–36.PubMedGoogle Scholar
  6. 6.
    The Research-subcommittee of the Empire Rheumatism Council. Gold therapy in rheumatoid arthritis. Ann Rheum Dis 1960, 19, 95–119.Google Scholar
  7. 7.
    The Research-subcommittee of the Empire Rheumatism Council. Gold therapy in rheumatoid arthritis. Ann Rheum Dis 1961, 20, 315–334.Google Scholar
  8. 8.
    Mascarenhas, B.R., Granda, J.L., Freyberg, R.H. Gold metabolism in patients with rheumatoid arthritis treated with gold compounds-reinvestigated. Arthritis Rheum 1972, 15, 391–402.PubMedGoogle Scholar
  9. 9.
    Cats, A. A multicentre controlled trial of the effects of different dosage of gold therapy, followed by a maintenance dosage. Agents Actions 1976, 6, 355–363.PubMedGoogle Scholar
  10. 10.
    McCarty, D.J., Carrera, G.F. Treatment with combined cyclophosphamide, azathioprine, and hydroxychloroquine. JAMA 1982, 248, 1718–1723.PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • H. Van Der Leeden
    • 1
  • B. A. C. Dijkmans
    • 1
  • J. Hermans
    • 2
  • A. Cats
    • 1
  1. 1.Departments of RheumatologyUniversity HospitalRC LeidenThe Netherlands
  2. 2.Medical StatisticsUniversity HospitalRC LeidenThe Netherlands

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