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Clinical Rheumatology

, Volume 5, Issue 1, pp 25–32 | Cite as

Beta-endorphin, immunological and biochemical changes in synovial fluid in rheumatic disorders

  • Ch. W. Denko
  • J. Aponte
  • P. Gabriel
  • M. Petricevic
Originals

Summary

In 120 patients with rheumatic disorders concomitant assays of serum and synovial fluid were done for acute phase reactants, immunoglobulins and the neuropeptide beta-endorphin. One-third of the patients with rheumatoid disease demonstrated synovial fluid levels of endorphin to be several-fold higher than serum levels, while in two-thirds the opposite results were found. These changes are discussed as adaptive or defense mechanisms. The synovial membrane is postulated to synthesize beta-endorphin.

Key words

Beta-Endorphin Acute Phase Reactant Synovial Fluid Rheumatic Disorders 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Ch. W. Denko
    • 2
  • J. Aponte
    • 2
  • P. Gabriel
    • 1
  • M. Petricevic
    • 1
  1. 1.Research LaboratoryFairview General HospitalClevelandUSA
  2. 2.Department of MedicineCase Western Reserve UniversityClevelandUSA

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