Clinical Rheumatology

, Volume 5, Issue 1, pp 25–32 | Cite as

Beta-endorphin, immunological and biochemical changes in synovial fluid in rheumatic disorders

  • Ch. W. Denko
  • J. Aponte
  • P. Gabriel
  • M. Petricevic


In 120 patients with rheumatic disorders concomitant assays of serum and synovial fluid were done for acute phase reactants, immunoglobulins and the neuropeptide beta-endorphin. One-third of the patients with rheumatoid disease demonstrated synovial fluid levels of endorphin to be several-fold higher than serum levels, while in two-thirds the opposite results were found. These changes are discussed as adaptive or defense mechanisms. The synovial membrane is postulated to synthesize beta-endorphin.

Key words

Beta-Endorphin Acute Phase Reactant Synovial Fluid Rheumatic Disorders 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Swann, D.A. Macromolecules of synovial fluid. In: The Joints and Synovial Fluid. Ed: L. Sokoloff, Academic Press, New York 1978, 407–438.Google Scholar
  2. 2.
    Kobayashi, I., Ziff, M. Electron microscopic studies of lymphoid cells in rheumatoid synovial membrane. Arthritis Rheum 1973, 16, 471–486.PubMedGoogle Scholar
  3. 3.
    Denko, C.W., Gabriel, P. Serum proteins — transferrin, ceruloplasmin, albumin,α-acid glycoprotein,α 1-antitrypsin —- in rheumatic disorders. J. Rheumatol 1979, 6, 664–672.PubMedGoogle Scholar
  4. 4.
    Denko, C.W., Aponte, J., Gabriel, P., Petricevic, M. Serum beta-endorphins in rheumatic disorders. Accepted for publication in J Rheumatol 1982.Google Scholar
  5. 5.
    Rodnan, G.P., Schumacher, H.R. Eds. Zvaifler, N.J., Associate Ed. Primer on the Rheumatic Diseases. Eighth Edition, Arthritis Foundation, Atlanta, 1983.Google Scholar
  6. 6.
    Denko, C.W., Gabriel, P., Petricevic, M. Urinary excretion of material with beta-endorphin immunoreactivity. Clin Chem 1981, 27, 207–208.PubMedGoogle Scholar
  7. 7.
    Ritzman, S.E., Daniels, J.C. “Serum Protein Abnormalities”. Diagnostic and Clinical Aspects, 1st ed., Little, Brown and Company, Boston, 1975.Google Scholar
  8. 8.
    Denko, C.W., Gabriel, P. Age and sex-related levels of albumin, ceruloplasmin, antitrypsin, acid glycoprotein and transferrin. Ann Clin Lab Sci 1981, 11, 63–68.PubMedGoogle Scholar
  9. 9.
    Julliard, J.H., Shibasaki, T., Ling, N., Guillemin, R. High-molecular weight immunoreactiveβ-endorphin in extracts of human placenta is a fragment of immunoglobulin G. Science, 1980, 208, 183–185.Google Scholar
  10. 10.
    Wilkes, M.M., Stewart, R.D., Bruni, J.F., et al. A specific homologous radioimmunoassay for humanβ-endorphin: Direct measurement in biological fluids. J Clin Endocrinol Metab, 1980, 50, 309–315.PubMedGoogle Scholar
  11. 11.
    Denko, C.W. Protective role of ceruloplasmin in inflammation. Agents Actions 1979, 9, 333–336.PubMedGoogle Scholar
  12. 12.
    Denko, C.W., Wanek, K. Anti-inflammatory action of acidglycoprotein. Agents Actions 1984, 15, 539–540.PubMedGoogle Scholar
  13. 13.
    Denko, C.W. Phlogistic properties of the serum proteins, albumin and transferrin. Inflammation 1980, 4, 165–168.PubMedGoogle Scholar
  14. 14.
    Pitt, E., Lewis, D.A. Anti-inflammatory properties of alpha-1-antitrypsin. Inter J Tissue Reactions 1979, 1, 21–32.Google Scholar
  15. 15.
    Kushner, I., Somerville, J.A. Permeability of human synovial membrane to plasma proteins. Relationship to molecular size and inflammation. Arthritis Rheum 1971, 14, 560–570.PubMedGoogle Scholar
  16. 16.
    Denko, C.W. Regeneration, repair and their control by pharmacologic agents, Chapter 10 in Handbook of Inflammation, Vol. 5, Eds: Bonta, I., Bray, M.A., Parnham, M.J. Elsevier Science Publishers B.V. 1985.Google Scholar
  17. 17.
    Ferreira, S.H., Nakamura, M. Pathogenesis and pharmacology of pain. In: Advances in Inflammation Research, Ed: G. Weissmann, Raven Press, 1979, 1, 317–329.Google Scholar
  18. 18.
    Denko, C.W., Petricevic, M. Prostaglandin A2 and35S uptake in connective tissue. Prostaglandins 1977, 14, 701–707.PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Ch. W. Denko
    • 2
  • J. Aponte
    • 2
  • P. Gabriel
    • 1
  • M. Petricevic
    • 1
  1. 1.Research LaboratoryFairview General HospitalClevelandUSA
  2. 2.Department of MedicineCase Western Reserve UniversityClevelandUSA

Personalised recommendations