Skip to main content

Advertisement

SpringerLink
Log in

Plasma fibronectin in psoriatic arthritis subgroups

  • Originals
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Summary

Plasma from 38 patients suffering from one of the five broad clinical subgroups of Psoriatic Arthritis (PA) were studied for soluble plasma Fibronectin (pFn). The mean total concentration of pFn was 453.03μg/ml ± 142.83 SD, with a significant statistical difference (p<0.01) versus a healthy control group matched with respect to sex and age. In order to evaluate the biological role that pFn might play in this pathological condition, observed concentrations were correlated with the degree and duration of the psoriasis and arthritis. In addition, pFn was correlated to some biohumoral parameters that are modified during inflammatory processes (ESR, CRP, sCu, sFe, Hb) and to uric acid levels. Tissue typing (HLA) was done where possible. From our observations, we suggest that pFn most likely is not an acute phase protein and rather than having specificity for a particular disease, might, in widespread and severe cases be,a general and useful marker of the connective-tissue organizing and repairing response, following its injury.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Mosher, D.F. Fibronectin, Prog Hemost Thromb, 1980, 5, 111–151.

    PubMed  CAS  Google Scholar 

  2. Saba, T.M., Jaffe, E. Plasma fibronectin (opsonic glycoprotein): its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial functions. Am J Med, 1980, 68, 577–594.

    Article  PubMed  CAS  Google Scholar 

  3. Menzel, E.J., Smolen, J.S., Liotta, L., Reid, K.B. Interaction of Fibronectin with Clq and its collagen-like fragment (CLF). FEBS Letters, 1981, 1, 188–192.

    Article  Google Scholar 

  4. Mosesson, M.W., Amrani, D.L. The structure and biologic activities of plasma fibronectin. Blood, 1980, 2, 145–158.

    Google Scholar 

  5. Carsons, S.E., Diamond, H.S. A possible role for fibronectin in inflammatory joint disease. Clin Res, 1980, 28, 342A.

    Google Scholar 

  6. Zardi, L., Cecconi, C., Barbieri, O., Carnemolla, B., Picca, M., Siri, A., Santi, L. Concentration of fibronectin of plasma of tumor-bearing mice and synthesis by Erich ascites tumor cells. Cancer Res, 1979, 9, 97–105.

    Google Scholar 

  7. Carsons, S.E., Mosesson, M.W., Diamond, H.S. Detection and quantitation of Fibronectin in synovial fluid from patients with rheumatic disease. Arthritis Rheum, 1981. 10, 1261–1267.

    Google Scholar 

  8. Clemmensen, I., Andersen, R.B. Different molecular forms of Fibronectin in rheumatoid synovial fluid. Arthritis Rheum, 1982, 1. 25–31.

    Article  Google Scholar 

  9. Todd, H.D., Coffea, M.S., Walkes, T.P., Abeloff, M.D., Parson, R.G. Serum levels of fibronectin and a fibronectin-like DNA-binding protein in patients with various diseases. JNCI. 1981, 5, 901–904.

    Google Scholar 

  10. Scott, D.L., WeiWright, A.C., Walton, K.W., Williamson, N. Significance of fibronectin in rheumatoid arthritis and osteorarthrosis. Ann Rheum dis, 1981, 40, 142–153.

    Article  PubMed  CAS  Google Scholar 

  11. Moll, J.M., Wright, V. Familial occurrence of psoriatic arthritis. Ann Rheum Dis, 1973, 32, 181–185.

    Article  PubMed  CAS  Google Scholar 

  12. Mosher, D.F., Williams, E.M. Fibronectin concentration is decreased in plasma of severely ill patients with disseminated intravascular coagulation. J Lab Clin Med, 1978, 91, 729–735.

    PubMed  CAS  Google Scholar 

  13. Gressner, A.M., Wallraff, P. Immunoturbidimetric measurement of cold insoluble globulin with reference to a laser nephelometric assay. J Clin Chem Biochem, 1981, 19, 1213–1215.

    CAS  Google Scholar 

  14. Saba, T.M., Albert, T.H., Blumenstock, F.A., Evanega, G., Staehler, F., Cho, E. Evaluation of a rapid immunoturbidimetric assay for opsonic fibronectin in surgical and trauma patients. J Lab Clin Med, 1981, 98, 482–491.

    PubMed  CAS  Google Scholar 

  15. Terasaki, P.I., McChelland, J., Park, M.S., Curdy, M.B. Microdroplet lymphocyte cytotoxicity test. In: Manual of tissue typing techniques. Editors: Ray J.G., More D.B., Pederson P.D. NIH Bethesda, 1974.

    Google Scholar 

  16. Cutolo, M., Rovida, S., Samantha, E., Accardo, S. Effect of drugs on serum copper and its correlation with other humoral factors in rheumatoid arthritis. In: Inflammation: Mechanisms and treatment. Editors: Willoughby D.A., Giroud J.P. MTP Lancaster, England. 1980, 453–458.

    Google Scholar 

  17. Green, L., Meyers, O.L., Gordon, W., Briggs, B. Arthritis in psoriasis. Ann Rheum Dis, 1981, 40, 366–370.

    Article  PubMed  CAS  Google Scholar 

  18. Latulippe, L., Azour, E.M. arthrite psoriasique: Analyse de 69 cas et revue de la littérature. CMA. 1979, 120, 1515–1518.

    CAS  Google Scholar 

  19. Loebl, D.H. Psoriatic arthritis. JAMA, 1979, 242, 2447–2451.

    Article  PubMed  CAS  Google Scholar 

  20. Mosher, D.F., Grossman, J.E. Clinical use of fibronectin. La Ricerca Clin. Lab. 1983, 9, 703–707.

    Google Scholar 

  21. Scott, D.L., Farr, M., Crockson, A.P., Walton, K.W. Synovial fluid fibronectin levels in rheumatoid arthritis. Clin Science, 1982, 62, 71–76.

    CAS  Google Scholar 

  22. Vartio, T., Vaheri, A., Von Essen, R., Isomäki, M., Stenman V. Fibronectin in synovial fluid and tissue in rheumatoid arthritis. Eur J Clin Invest, 1981, 11, 207–212.

    Article  PubMed  CAS  Google Scholar 

  23. Modena, V., Parizia, M.C., Galetto, G., Torone, C., Daneo, V., Zina, A. La fibronettina plasmatica in alcune connettiviti. Reum. XXXIII. 1981, 3, 351–353.

    Google Scholar 

  24. Carsons, S.E. Synovial fluid fibronectin. Eur J Clin Invest, 1982, 18, 8.

    Article  Google Scholar 

  25. Fraki, J.E., Jakoi, L., Davies, A.O., Lefkowitz, J.D., Jederberg, W.W., Torres, A.R. Polymorphonuclear leucocyte functions in psoriasis. Clin Res 1981, 39, 282A.

    Google Scholar 

  26. Weissmann, G., Pearlstein, E., Perez. H.D., Falkow, S., Goldstein, I.M., Hoffstein, S.T. Neutrophils synthesize and deposit fibronectin on surfaces to which they attach. 1983 Trans Assoc Am Phys (in press).

  27. Krueger, G.G., Chambers, D.A., Stubbs, J.D., Jederberg, W.W., Torres, A.R. A role for humoral factors in psoriasis. J Lab Clin Med. 1982, 99, 275–287.

    PubMed  CAS  Google Scholar 

  28. Postlethwaite, A.E., Keski-Oja, J., Balian, G., Kang, A. Induction of fibroblasts chemotaxis by fibronectin. J Exp Med, 1981, 153, 494–499.

    Article  PubMed  CAS  Google Scholar 

  29. Vinjie, O., Møller O., Mellbye, O. Laboratory findings in patients with psoriasis, with special reference to immunological parameters, associations with arthropathy and sacro-iliitis. Scand J Rheumatol, 1980, 9, 97–105.

    Article  PubMed  Google Scholar 

  30. Gerber, L., Murray, C., Parman, S.G., Barth, W.F., Decker, J.L., Nigra, T.A., Mann, D.L. Human lymphocyte antigens characterizing psoriatic arthritis and its subtypes. J. Rheumatol, 1982, 9, 703–707.

    PubMed  CAS  Google Scholar 

  31. Armstrong, R.D., Panayi, G.S., Welsh, K.F. Histocompatibility antigens in psoriasis, psoriatic arthropathy and ankylosing spondylitis. Ann Rheum Dis, 1983, 42, 142–146.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Rheumatological Centre, University of Genoa, Genoa, Italy

    M. Cutolo, S. Accardo, M. A. Cimmino & S. Rovida

  2. Medical Statistics Institute, University of Genoa, Genoa, Italy

    S. Rovida

Authors
  1. M. Cutolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Accardo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. A. Cimmino
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Rovida
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cutolo, M., Accardo, S., Cimmino, M.A. et al. Plasma fibronectin in psoriatic arthritis subgroups. Clin Rheumatol 3, 129–136 (1984). https://doi.org/10.1007/BF02030745

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02030745

Key words

Search

Navigation