Abstract
Twenty-eight patients with gastric cancer were treated by photodynamic therapy. Haematoporphyrin derivative was used as a photosensitizer and an argon dye laser as a light source. Histologically, all tumours were adenocarcinomas. On the basis of endoscopy, 17 cases were categorized as early-stage cancer and were classified as type IIc (10 lesions), Ha (three lesions), combined type IIc and type III (three lesions) and type I (two lesions). In 11 patients with advanced-stage cancer, endoscopy showed one case of Borrmann I, three of Borrmann II, six of Borrmann III and a single case of Borrmann IV. In the 17 patients with early-stage cancers (18 lesions), complete remission was obtained in 10 patients (11 lesions). Of 13 resected cancers complete remission was confirmed in six lesions on the basis of detailed histological examination of resected specimens. In the advanced stage tumours all 11 patients showed incomplete remissions. It is considered that an incomplete response in the early-stage cancers is due to insufficient light dosage because of the wide area of tumour, because the site of the lesion is anatomically difficult to photoradiate and because the invasion extends to the muscular layer and serosa.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Tappeiner H, Jesionek A. Therapeutische Versuche mit fluoreszierenden Stoffe.Muench Med Wochenschr 1903,1:2042–4
Lipson RL, Baldes EJ. The photodynamic properties of a particular hematoporphyrin derivative.Arch Dermatol 1960,82:508–16
Gomer CJ, Doiron DR, Rucker N et al. Examination of action spectrum, dose rate and mutagenic properties of hematoporphyrin derivative in photoradiation therapy. In: Doiron DR, Gomer CJ (eds)Porphyrin localization and treatment of tumors. New York: Alan R. Liss Inc. (Prog Clin Biol Res 170) 1984:459–69
Dougherty TJ, Grindey GB, Weishaupt KR, Boyle D. Photoradiation therapy. II: Cure of animal tumors with hematoporphyrin and light.J Natl Cancer Inst 1975,55:115–21
Dougherty TJ, Kaufman JE, Goldfalb A et al. Photoradiation therapy for the treatment of malignant tumors.Cancer Res 1978,38:2628–35
Hayata Y, Kato H, Konaka C et al. Fiberoptic bronchoscopic photoradiation in experimentally induced canine lung cancer.Cancer (Phila) 1983,51:50–6
Kato H, Konaka C, Ono J et al. Effectiveness of HpD and radiation therapy in lung cancer. In: Kessel D, Dougherty TJ (eds)Porphyrin photosensitization. New York: Plenum (Adv Exp Med Biol 160) 1983:23–9
Hayata Y, Kato H, Konaka C et al. Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer.Chest 1982,81:269–77
Definition of early carcinoma of the stomach. Editorial.I To Cho (Stomach Intest) 1982,17:8
Hayata Y, Dougherty TJ.Lasers and hematoporphyrin derivative in cancer. Tokyo: Igaku-Shoin, 1983
Figge FHJ, Weiland GS, Manganiello LOJ. Cancer detection and therapy. Affinity of neoplastic, embryonic, and traumatized tissues for porphyrins and metallo-porphyrins.Proc Soc Exp Biol Med 1948,68:640–1
Sanderson DR, Fontana RS, Lipson RL, Baldes EJ. Hematoporphyrin as a diagnostic tool. A preliminary report of new techniques.Cancer (Phila) 1972,30:1368–72
Tomson SH, Emmett EA, Fox SH. Photodestruction of mouse epithelial tumors after oral acridine orange and argon laser.Cancer Res 1974,34:3124–6
Otawa M, Aizawa K, Kato H et al. Basic study concerning tissue penetration of laser beam.Gendai-No-Shinryo 1982,24:25–9
Weishaupt KR, Gomer CJ, Dougherty TJ. Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor.Cancer Res 1976,36:2326–9
Sakai H, Aizawa K, Kato H, Hayata Y. Detection of singlet oxygen from HpD using luminol.J Tokyo Med Coll 43:6 (in press)
Kessel D. Effects of photoactivated porphyrins at the cell surface of leukemia L1210 cells.Biochemistry 1977,16:3443–9
Moan J, Steen HB, Ferer K, Christensen T. Uptake of hematoporphyrin derivative in cells of different oncogenic potential.Cancer Lett 1981,14:291–6
Saito M, Kato H, Konaka C et al. Affinity of HpD for mitochondriaIgaku-No-Ayumi 1985,132:600–2
Kato H, Aizawa K, Shinohara H et al. Cytomorphological changes caused by hematoporphyrin derivative and photodynamic therapy.Lasers in the Life Sciences (in press)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kato, H., Kawaguchi, M., Konaka, C. et al. Evaluation of photodynamic therapy in gastric cancer. Laser Med Sci 1, 67–74 (1986). https://doi.org/10.1007/BF02030738
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02030738