Summary
In an attempt to find a serological marker for neuropsychiatric manifestations (NPM) of SLE, sera from 66 patients (classified in three groups, according to their NPM — defined, probable and without NPM) were analysed by ELISA for IgG and IgM anticardiolipin, antigangliosides and antigalactocerebrosides antibodies. A strong correlation was found between IgM antigangliosides and antigalactocerebrosides antibodies and NPM, but not with IgG class. IgM and IgG antibodies anticardiolipin were not correlated with NPM in this study. Both IgM antigangliosides and antigalactocerebrosides antibodies disappeared in seven patients with definite but clinically inactive NPM. The analysis of these autoantibodies showed an important role predictive for NPM in SLE; the negative test decreases the chance of the NPM.
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Abel, T., Gladman, D.P., Urowitz, M.B. Neuropsychiatric lupus. J Rheumatol 1980, 7, 325.
Dubois, E.L., Tuffanelli, D.E. Clinical manifestations of systemic lupus erythematosus. J Am Med Assoc 1964, 190, 104.
Ellis, S.G., Verity, A.M. Central nervous system involvement in systemic lupus erythematosus. A review of neuropathologic findings in 57 cases, 1955–1977. Semin Arthritis Rheum 1975, 8, 212.
Estes, D., Christian, C.L. The natural history of systemic lupus erythematosus studied by prospective analyses. Medicine 1971, 50, 85.
Grigor, R., Edmonds, J., Leukonia, R., et al: Systemic lupus erythematosus. A prospective analysis. Ann Rheum Dis, 1978, 37, 121.
Johnson, R.T., Richardson, E.P. The neurologic manifestations of systemic lupus erythematosus: a clinical-pathological study of 24 cases and review of the literature. Medicine 1968, 47, 337.
Lee, P., Urowitz, M.B., Bookman, A.A., et al: Systemic lupus erythematosus. Q J Med 1977, 46, 1.
Steinman, C.R. Circulating DNA in systemic lupus erythematosus. Association with central nervous system involvement and systemic vasculitis. Am J Med 1979, 67, 429.
Winfield, J.B., Brunner, C.M., Koffler, D. Serologic studies in patients with systemic lupus erythematosus and central nervous system dysfunction. Arthritis Rheum 1978, 21, 289.
Wilson, H.A., Winfield, J.B., Lahita, R.G., et al: Association of IgG anti-brain antibodies with central nervous system dysfunction in systemic lupus erythematosus. Arthritis Rheum 1979, 22, 458.
Golombeck, S.J., Graus, F., Elkon, K.B. Autoantibodies in the cerebrospinal fluid of patients with systemic lupus erythematosus. Arthritis Rheum 1986, 29, 1090.
Bluestein, H.G., Zvaifler, N.J. Brain-reactive lymphocitotoxic antibodies in the serum of patients with systemic lupus erythematosus. J Clin Invest 1976, 57, 509.
Bresnihan, B., Oliver, M., Grigor, R., Hughes, G.R.V. Brain reactivity of lymphocytotoxic antibodies in systemic lupus erythematosus with and without cerebral involvement. Clin Exp Immunol 1977, 30, 333.
Quismorio, F.P., Friou, G.J. Antibodies reactive with neurons in SLE patients with neuropsychiatric manifestations. Int Arch Allergy Appl Immunol, 1972, 43, 740.
Bluestein, H.G. Heterogenous neurocytotoxic antibodies in systemic lupus erythematosus. Clin Exp Immunol, 1979, 35, 210.
Bluestein, H.G., Williams, G.W., Steinberg, A.D. Cerebrospinal fluid antibodies to neuronal cells: Association with neuropsychiatric manifestations of systemic lupus erythematosus. Am J Med 1981, 70, 240.
Bresnihan, B., Oliver, M., Williams, B., et al. An antineuronal antibody cross-reacting with erythrocytes and lymphocytes in systemic lupus erythematosus. Arthritis Rheum 1979, 22, 313.
Golub, E.S. III Brain-associated erythrocyte antigen: An antigen shared by brain and erythrocytes. Exp Hematol 1973, 1, 105.
Bonfa, E., Golombek, S.J., Kaufman, L.D., et al. Association between lupus psychosis and anti-ribomosal P protein antibodies. N Engl J Med 1987, 317, 265.
Firlan, B.G., Howard, M.A., Radford, N. Possible relationship between the lupus inhibitor and recurrent abortion in young women. Lancet 1980, 11, 366.
Harris, E.N., Body, M.L., Young, C.G.M., et al. Anticardiolipin antibodies: detection by radio-immunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983, 26, 1211.
Hughes, G.R.V. Central nervous system lupus-diagnosis and treatment. J Rheumatol 1980, 7, 405.
Laurell, A.B., Nilsson, I.M. Hypergammaglobulinema, circulating antigoagulant, and biologic false positive Wasserman. J Lab Clin Med 1957, 49, 694.
Lechner, K. Acquired inhibitors in nonhaemophilic patient. Haemostasis, 1974, 3, 65.
Scheider, M.A., Nachman, R.I., Jaffe, E.A., Coleman, M. A clinical study of lupus anticoagulant. Blood 1976, 48, 499.
Wilson, A., Hughes, G.R.V. Aetiology of Jamaican neuropathy. Lancet 1975, 1, 240.
Hirano, T., Hashimoto, H., Shiokawa, Y., et al: Antiglycolipid autoantibody detected in the sera from systemic lupus erythematosus patients. J Clin Invest 1980, 66, 1437.
Endo, T., Scott, D.D., Stewart, S.S., et al. Antibodies to glycosphingolipids in patients with multiple sclerosis and SLE Adv Exp Med Biol 1984, 174, 455.
Tan, E.M., Cohen, A.S., Fries, J.F., et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum, 1982, 25, 1271.
How, A., Dent, P.B., Liao, S.K., et al. Antineuronal antibodies in neuropsychiatric systemic erythematosus. Arthritis Rheum 1985, 28, 789.
Friou, G.L., Finch, S.C., Detre, K.D. Interaction of nuclei and globulin from lupus erythematosus serum demonstrated with fluorescent antibody. J Immunol 1958, 80, 324.
Parker, M.D., Kerby, G.P. Combined titer and fluorescent pattern of IgG antinuclear antibodies using cultured cell monolayers in evaluating connective tissue diseases. Ann Rheum Dis 1974, 33, 465.
Singer, J.M., Plotz, C.M. Slide latex fixation test. JAMA, 1958, 168, 180.
Growe, W., Kushner, I. An immunofluorescent method using Crithidia lucilliae to detect antibodies to double-stranded DNA. Arthritis Rheum 1977, 20, 881.
Sharp, G.C., Irvin, W.S. Hemagglutinating antibody to DNA and to the extractable nuclear antigen in systemic lupus erythematosus. Arthritis Rheum 1968, 11, 116.
Tan, E.M., Kunkel, H. Characteristics of a soluble nuclear antigen precipitating with sera of patients with systemic lupus erythematosus. J Immunol 1966, 96, 464.
Canoso, R.T., Oliveira, R.M. Chlorpromazyne-induced anticardiolipin antibodies and lupus anticoagulant: Absence of thrombosis. Am J Hematol 1988, 27, 272.
Rapport, M.M., Graf, L., Skipski, V.P. Cytolipin H, a pure lipid hapten isolated from human carcinome. Nature 1958, 181, 1803.
Karpiak, S.E., Graf, L., Rapport, M.M. Antiserum to brain gangliosides produces recurrent epilepti form activity. Science (Wash DC), 1976, 194, 735.
Sergott, R.C., Brown, M.J., Silberberg, D.H., et al. Antigalactocerebroside serum demyelinates optic nerve in vivo. J Neurol Science, 1984, 64, 297.
Tsukada, N., Koh, C.S., Yanagiswa, N., et al. Peripheral nervous tissue injury induced by galactocerebrosides and galactocerebrosides immune complexes. Acta Neuropathol (Berl), 1985, 66, 274.
Sotskii, O.P., et al. Cerebrosides as one of the factors regulating the functional state of the blood vascular wall system. Biull Eksp Biol Med, 1984, 97, 387. (Eng. abst Russ).
Yokoyama, M., Trams, E.G., Brady, R.O. Sphingolipid antibodies in sera of animals and patients with central nervous system lesions. Proc Soc Exp Biol Med 1962, 111, 350.
Arnon, R., Crisp, E., Kelley, R., Ellison, G.W., Myers, L.W., Tourtelleto, W.W. Anti-gangliode antibodies in multiple sclerosis. J Neurol Sci 1980, 46, 179.
Endo, T., Scott, D.D., Stewart, S.S., Kundu, S.K., Marcus, D.M. Antibodies to glycosphingolipids in patients with multiple sclerosis and SLE. Adv Exp Med Biol 1984, 174, 455.
Hirsch, H.E., Parks, M.E. Serological reactions against glycolipid sensitised liposomes in multiple sclerosis. Nature 1976, 264, 785.
Fulford, K.W.M., Catterall, R.D., Delhanty, J.J., et al. A collagen disorder of the nervous system presenting as multiple sclerosis. Brain 1972, 95, 373.
Holmes, F.F., Stubbs, D.N., Larsen, W.E. Systemic lupus erythematosus and multiple sclerosis in identical twins. Arch Intern Med 1967, 119, 302.
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Costallat, L.T.L., de Oliveira, R.M., Santiago, M.B. et al. Neuropsychiatric manifestations of systemic lupus erythematosus: The value of anticardiolipin, antigangliosides and antigalactocerebrosides antibodies. Clin Rheumatol 9, 489–497 (1990). https://doi.org/10.1007/BF02030510
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DOI: https://doi.org/10.1007/BF02030510