Summary
The advoidance response times for 4,400 runs in a shuttlebox under extinction procedure were measured for 22 rats, 20 minutes after exposure to filtered and unfiltered cigarette smoke. The test conditions of full smoke (5 and 10 puffs) and charcoal-filtered smoke (10 puffs) differed significantly from the control and Cambridge-charcoal filter conditions (10 puffs) in the direction of inhibiting extinction (i. e. shortening of the response times). As the test conditions of full smoke and charcoal-filtered smoke were the only ones which contained the particulate phase, of which nicotine is pharmacologically by far the most active ingredient, this stimulating effect was attributed to nicotine. The stimulating effect commonly observed in behavioral experiments through nicotine injection has therefore been demonstrated here through the medium of small controlled doses of cigarette smoke, comparable to the non-toxic intake of this substance by humans.
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This study was conducted with the help of a grant from the Swiss Association of Cigarette Manufacturers.
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Driscoll, P., Bättig, K. The effect of filtrate fractions of tobacco smoke on the avoidance behavior of rats under extinction procedure. Z. Prāventivmed 16, 197–203 (1971). https://doi.org/10.1007/BF02030436
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DOI: https://doi.org/10.1007/BF02030436