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Alterations in vitamin A metabolism by polyhalogenated aromatic hydrocarbons

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Summary

Adequate stores and adequate tissue levels of vitamin A are maintained by a balance of tissue demands and dietary intake of the vitamin and are modified by many factors, including xenobiotics. It is well established that exposure to polyhalogenated aromatic hydrocarbons (PHAH) decreases hepatic content of vitamin A. Recent findings indicate that hepatic depletion of vitamin A is accompanied by an increase in serum and renal vitamin A content and enhanced excretion of vitamin A metabolites in urine and feces. Examination of tissue retinoid profiles reveals that PHAH exposure causes the generation of increased amounts of polar retinoids. It is very likely that PHAH affect enzymes crucial for regulation of vitamin A storage as well as enhance activities of specific enzymes in vitamin A metabolic pathway.

Zusammenfassung

Ausreichende Vitamin-A-Speicher und -Gewebslevel werden durch ein Gleichgewicht von Nachfrage der Gewebe nach Vitamin A und der Vitamin-A-Aufnahme durch die Nahrung aufrechterhalten und durch viele Faktoren beeinflußt.

Es ist hinreichend bekannt, daß polyhalogenierte aromatische Kohlenwasserstoffe (PHAH) die Vitamin-A-Speicher der Leber erniedrigen. Neuere Untersuchungen deuten darauf hin, daß die Erniedrigung der Vitamin-A-Leberspeicher von einem Anstieg des Vitamin-A-Gehaltes in Serum und Niere sowie von einer erhöhten Abgabe von Vitamin-A-Metaboliten in Urin und Fäzes begleitet sind. Die Untersuchung der Vitamin-A-Verteilung in verschiedenen Geweben zeigte, daß die Zufuhr von PHAH zu einem verstärkten Auftreten polarer Vitamin-A-Metaboliten führt. Es ist wahrscheinlich, daß die PHAH Enzyme beeinflussen, die entscheidend für die Regulation von Vitamin-A-Speichern sowie der Aktivität von für den Vitamin-A-Stoffwechsel wichtigen Enzymen sind.

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  1. M. H. Zile

    Present address: Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA

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  1. Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA

    P. A. Bank & I. A. Roltsch

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Herrn Prof. Dr. med. Karl Heinz Bässler zum 65. Geburtstag gewidmet

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Zile, M.H., Bank, P.A. & Roltsch, I.A. Alterations in vitamin A metabolism by polyhalogenated aromatic hydrocarbons. Z Ernährungswiss 28, 93–102 (1989). https://doi.org/10.1007/BF02030126

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