European Journal of Clinical Microbiology

, Volume 2, Issue 3, pp 213–215 | Cite as

Fatal meningitis with group JKCorynebacterium in a leucopenic patient

  • S. Hoffmann
  • H. Ersgaard
  • T. Justesen
  • H. Friis
Case Report


A case of fatal meningitis and septicemia with group JKCorynebacterium species in a leucopenic patient is reported. The strain was susceptible to rifampicin and vancomycin only. The finding of diphtheroids in bacteriological samples from immunocompromised patients should not be ignored. The literature regarding meningitis caused by diphtheroid bacilli is reviewed.


Internal Medicine Meningitis Vancomycin Rifampicin Immunocompromised Patient 
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  1. 1.
    Hande, K. R., Witebsky, F. G., Brown, M. S., Schulman, C. B., Anderson, S. E., Levine, A. S., MacLowry, J. D., Chabner, B. A.: Sepsis with a new species ofCorynebacterium. Annals of Internal Medicine 1976, 85: 423–426.PubMedGoogle Scholar
  2. 2.
    Pearson, T. A., Braine, H. G., Rathbun, H. K.:Corynebacterium sepsis in oncology patients. Predisposing factors, diagnosis, and treatment. Journal of the American Medical Association 1977, 238: 1737–1740.CrossRefPubMedGoogle Scholar
  3. 3.
    Stamm, W. E., Tompkins, L. S., Wagner, K. F., Counts, G. W., Thomas, E. D., Meyers, J. D.: Infection due toCorynebacterium species in marrow transplant patients. Annals of Internal Medicine 1979, 91: 167–173.PubMedGoogle Scholar
  4. 4.
    Young, V. M., Meyers, W. F., Moody, M. R., Schimpff, S. C.: The emergence of coryneform bacteria as a cause of nosocomial infections in compromised hosts. American Journal of Medicine 1981, 70: 646–650.CrossRefPubMedGoogle Scholar
  5. 5.
    Clapper, W. E., Carlquist, J. H.: Brain abscess and meningitis caused by a diphtheroid resemblingCorynebacterium ulcerogenes. Proceedings of the Society for Experimental Biology and Medicine 1945, 60: 298–301.Google Scholar
  6. 6.
    Dick, G. F.: A case of cerebrospinal meningitis due to a diphtheroid bacillus. Journal of the American Medical Association 1920, 74: 84.Google Scholar
  7. 7.
    Everett, E. D., Eickhoff, T. C., Simon, R. H.: Cerebrospinal fluid shunt infections with anaerobic diphtheroids (Propionibacterium species). Journal of Neurosurgery 1976, 44: 580–584.PubMedCrossRefGoogle Scholar
  8. 8.
    Gibson, H. J.: A pathogenic diphtheroid bacillus from a fatal case of meningitis. Journal of Pathology and Bacteriology 1935, 41: 239–252.CrossRefGoogle Scholar
  9. 9.
    Graber, C. D., Higgins, L. S., Davis, J. S.: Seldomencountered agents of bacterial meningitis. Journal of the American Medical Association 1965, 192: 956–960.PubMedGoogle Scholar
  10. 10.
    Kaplan, K., Weinstein, L.: Diphtheroid infections of man. Annals of Internal Medicine 1969, 70: 919–929.PubMedGoogle Scholar
  11. 11.
    Kessel, L., Romanoff, A.: General infections with a diphtheroid bacillus complicated by diphtheroid meningitis. Journal of the American Medical Association 1930, 94: 1647–1648.Google Scholar
  12. 12.
    Kimbrell, O. C.:Corynebacterium acnes — a cause of meningitis. North Carolina Medical Journal 1964, 25: 516–519.PubMedGoogle Scholar
  13. 13.
    Miller, M. K., Lyon, M. W.: Case of meningitis in an infant due to a thread-like diphtheroid organism. American Journal of the Medical Sciences 1941, 162: 593–598.CrossRefGoogle Scholar
  14. 14.
    Shaw, C. S., Turk, D. C.: A case of meningitis apparently caused by aCorynebacterium. Journal of Pathology and Bacteriology 1954, 68: 627–631.CrossRefPubMedGoogle Scholar
  15. 15.
    Tesdal, M.: Fatal meningitis caused by aCorynebacterium. Acta Medica Scandinavica 1934, 83: 351–358.CrossRefGoogle Scholar
  16. 16.
    Torregrosa, M. V.: Infrequently encountered infections with gram-positive bacilli. American Journal of Clinical Pathology 1968, 50: 689–691.PubMedGoogle Scholar
  17. 17.
    Bornstein, D. L., Weinberg, A. N., Swartz, M. N., Kunz, L. J.: Anaerobic infections — review of current experience. Medicine 1964, 43: 207–232.PubMedGoogle Scholar
  18. 18.
    Hitchcock, E., Andreadis, A.: Subdural empyema: a review of 29 cases. Journal of Neurology, Neurosurgery, and Psychiatry 1964, 27: 422–434.CrossRefPubMedGoogle Scholar
  19. 19.
    Johnson, W. D., Kaye, D.: Serious infections caused by diphtheroids. Annals of the New York Academy of Sciences 1974, 74: 568–576.Google Scholar
  20. 20.
    Riley, P. S., Hollis, D. G., Utter, G. B., Weaver, R. E., Baker, C. N.: Characterization and identification of 95 diphtheroid (group JK) cultures isolated from clinical specimens. Journal of Clinical Microbiology 1979, 9: 418–424.PubMedGoogle Scholar
  21. 21.
    Teele, D. W., Dashefsky, B., Rakusan, T., Klein, J. O.: Meningitis after lumbar puncture in children with bacteremia. New England Journal of Medicine 1981, 305: 1079–1081.PubMedCrossRefGoogle Scholar

Copyright information

© Vieweg Publishing 1983

Authors and Affiliations

  • S. Hoffmann
    • 1
  • H. Ersgaard
    • 1
  • T. Justesen
    • 1
  • H. Friis
    • 2
  1. 1.Department of Clinical Bacteriology, Institute of Medical MicrobiologyUniversity of CopenhagenCopenhagenDenmark
  2. 2.Department of MedicineThe Finsen InstituteCopenhagenDenmark

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