European Journal of Pediatrics

, Volume 154, Issue 6, pp 497–497 | Cite as

The prevalence of the G985 allele of medium-chain acyl-CoA dehydrogenase deficiency among sudden infant death victims and healthy newborns in northern Germany

  • R. Santer
  • N. Gregersen
  • K. Tanaka
  • C. Hinck-Kneip
  • M. Krawinkel
  • J. Schaub
Letters to the Editors

Keywords

Public Health Infant Death Dehydrogenase Deficiency G985 Allele Healthy Newborn 

Abbreviations

MCAD

medium-chain acyl-CoA dehydrogenase

SID

sudden infant death

References

  1. 1.
    Gregersen N, Blakemore AIF, Winter V, et al (1991) Specific diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in dried blood spots by a polymerase chain reaction (PCR) assay detecting a point-mutation (G985) in the MCAD gene. Clin Chim Acta 203: 23–34CrossRefPubMedGoogle Scholar
  2. 2.
    Gregersen N, Winter V, Curtis D, et al (1993) Medium-chain acyl-CoA dehydrogenase deficiency: the prevalent mutation G985 (K304E) is subject to a strong founder effect from northwestern Europe. Hum Hered 43: 342–350PubMedGoogle Scholar
  3. 3.
    Yokota I, Coates PM, Hale DE, Rinaldo P, Tanaka K (1991) Molecular survey of a prevalent mutation,985A-to-G transition, and identification of five infrequent mutations in the medium-chain acyl-CoA dehydrogenase (MCAD) gene in 55 patients with MCAD deficiency. Am J Hum Genet 49: 1280–1291PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • R. Santer
    • 1
  • N. Gregersen
    • 2
  • K. Tanaka
    • 3
  • C. Hinck-Kneip
    • 1
  • M. Krawinkel
    • 1
  • J. Schaub
    • 1
  1. 1.Department of PaediatricsUniversity of KielKielGermany
  2. 2.Center for Medical Molecular BiologyUniversity of AarhusAarhus NDenmark
  3. 3.Department of Human GeneticsYale UniversityNew HavenUSA

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