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European Journal of Pediatrics

, Volume 154, Issue 6, pp 497–497 | Cite as

The prevalence of the G985 allele of medium-chain acyl-CoA dehydrogenase deficiency among sudden infant death victims and healthy newborns in northern Germany

  • R. Santer
  • N. Gregersen
  • K. Tanaka
  • C. Hinck-Kneip
  • M. Krawinkel
  • J. Schaub
Letters to the Editors

Keywords

Public Health Infant Death Dehydrogenase Deficiency G985 Allele Healthy Newborn 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

MCAD

medium-chain acyl-CoA dehydrogenase

SID

sudden infant death

References

  1. 1.
    Gregersen N, Blakemore AIF, Winter V, et al (1991) Specific diagnosis of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in dried blood spots by a polymerase chain reaction (PCR) assay detecting a point-mutation (G985) in the MCAD gene. Clin Chim Acta 203: 23–34CrossRefPubMedGoogle Scholar
  2. 2.
    Gregersen N, Winter V, Curtis D, et al (1993) Medium-chain acyl-CoA dehydrogenase deficiency: the prevalent mutation G985 (K304E) is subject to a strong founder effect from northwestern Europe. Hum Hered 43: 342–350PubMedGoogle Scholar
  3. 3.
    Yokota I, Coates PM, Hale DE, Rinaldo P, Tanaka K (1991) Molecular survey of a prevalent mutation,985A-to-G transition, and identification of five infrequent mutations in the medium-chain acyl-CoA dehydrogenase (MCAD) gene in 55 patients with MCAD deficiency. Am J Hum Genet 49: 1280–1291PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • R. Santer
    • 1
  • N. Gregersen
    • 2
  • K. Tanaka
    • 3
  • C. Hinck-Kneip
    • 1
  • M. Krawinkel
    • 1
  • J. Schaub
    • 1
  1. 1.Department of PaediatricsUniversity of KielKielGermany
  2. 2.Center for Medical Molecular BiologyUniversity of AarhusAarhus NDenmark
  3. 3.Department of Human GeneticsYale UniversityNew HavenUSA

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