Pharmaceutisch Weekblad

, Volume 9, Issue 4, pp 198–202 | Cite as

Polarographic determination of extraction constants

  • H. A. Dingjan
  • W. P. Van Bennekom
  • A. Bult
Original Articles

Abstract

The extraction contants of three organic compounds containing nitrogen as a picrate ion pair in a water-chloroform system were determined by following polarographically the picrate concentration in the aqueous phase as a function of the added amount of reagent. The extraction constants were also determined spectrophotometrically (via batch extraction). The obtained results are in good agreement. The proposed method is applicable for extraction constants with values between 103 and 109.

Key words

Extraction constants Polarography Procaine Promethazine Spectrophotometry Tetrabutylammonium bromide Titrimetry, two-phase 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1987

Authors and Affiliations

  • H. A. Dingjan
    • 1
  • W. P. Van Bennekom
    • 1
  • A. Bult
    • 1
  1. 1.Department of Chemical Pharmacy, Subfaculty of PharmacyState University of UtrechtGH UtrechtThe Netherlands

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