Summary
It is widely accepted that a disturbed blood supply of the optic disc may cause (in addition with an increased intraocular pressure) optic nerve fibre damage. Therefore we measured ocular perfusion pressures in 79 healthy subjects. In 18 patients with low tension glaucoma, in 27 patients suffering from ocular hypertension and in 49 glaucoma (OAG) patients. For measuring perfusion pressures we used the technique of oculooscillo-dynamography (OODG) as described by Ulrich. Additionally we measured intraocular pressure and systemic blood pressure. In OODG the IOP is simultaneously increased in both eyes by application of a suction cup. After increase of the IOP the negative pressure in the suction cup is slowly and linearly decreased. During this decrease the pulse-depending oscillations of each eye are recorded on a strip-chart-recorder. By means of this method retinal and ciliary perfusion pressures can be separated. As a result we could show that mean arterial blood pressure and systolic retinal perfusion pressure were comparable and not statistically significantly different between the groups examined. The systolic ocular perfusion pressures in patients with low tension glaucoma showed a highly statistically significant reduction compared with the other groups. Between healthy subjects, OAG-patients and patients suffering from ocular hypertension there was no difference in systolic ciliary perfusion pressure detectable.
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References
Anderson DR. The posterior segment of glaucomatous eyes. In: Lütjen-Drecoll E ed. Basic aspects of glaucoma research. Stuttgart-New York: Schattauer 1982; 167–187
Christ Th, Stodtmeister R, Pillunat L. Okuläre Hämodynamik bei Zentral- und Astarterienverschlüssen. Klin Mbl Augenheilk 1985; 187: 443–445
Christ Th, Stodtmeister R, Pillunat L. Okulo-oszillo-dynamographie nach Ulrich: Erste Ergebnisse bei Carotisstenosen. Klin Mbl Augenheilk 1985; 187: 256–261
Drance SM. Some factors in the production of low tension glaucoma. Br J Ophthalmol 1972; 56: 229–242
Drance SM, Sweeny VP, Morgan RW, Feldman F. Studies of factors involved in the preduction of low tension glaucoma. Arch Ophthalmol 1973; 89: 457–465
Drance SM. Low tension glaucoma. —Enigma and Opportunity. Arch Ophthalmol 1985; 103: 1131–1133
Francois J, Neetens A. The deterioration of the visual field in glaucoma and the blood pressure. Doc Ophthalmol 1970; 28: 70–132
Gee W, Smith CA, Hinson CE, Wylie EJ. Ocular pneumoplethysmography in carotid artery disease. Med Instrumentation 1974; 8: 244–249
Gee W, Oller DW, Homer LD, Clifton Bailey R. Simultaneous bilateral determination of the systolic pressure of the ophthalmic artery by ocular pneumoplethysmography. Invest Ophthalmol Vis Sci 1977; 16: 86–92
Geijer C, Bill A. Effects of raised intraocular pressure on retinal, prelaminar, laminar and retrolaminar optic nerve blood flow in monkeys. Invest Ophthalmol Vis Sci 1979; 18: 1030–1036
Janpol LM, Board RJ, Maumanee AE. Systemic hypotension and glaucomatous changes. Am J Ophthalmol 1978; 85: 154–159
Janpol LM, Miller NR. Carotid artery disease and glaucoma. Br J Ophthalmol 1978; 62: 324–326
Leighton DR, Phillips CI. Systemic blood pressure in open angle glaucoma, low tension glaucoma and the normal eye. Br J Ophthalmol 1972; 56: 447–453
Phelps CD. The pathogenesis of optic nerve damage in glaucoma: a review of the vascular hypothesis. In: Blodi FC (ed): current concepts in ophthalmology. Vol. 3, St. Louis, Mosby 1972; 142–161
Pillunat LE, Stodtmeister R, Wilmanns I, Christ Th. New aspects in pressure tolerance of the optic nerve head. Invest Ophthalmol Vis Sci 1985; 26/3: 223
Pillunat LE, Stodtmeister R, Wilmanns I, Christ Th. Autoregulation of ocular blood flow during changes of intraocular pressure. Preliminary results. Graefes Arch Clin Exp Ophthalmol 1985; 223: 219–225
Pillunat LE, Stodtmeister R, Wilmanns I, Christ Th. Okuläre Kreislaufdiagnostik des Niederdruckglaukoms. Klin Mbl Augenheilk 1986; 188: 526–529
Pillunat LE, Stodtmeister R, Wilmanns I. Pressure compliance of the optic nerve head in low tension glaucoma. Br J Ophthalmol 1987; 71: 181–187
Richardson KT. Glaucoma and glaucoma suspects. In: Heilmann K, Richardson KT (eds) Glaucoma—conceptions of a disease. Thieme Stuttgart 1978, 2–20
Robert Y, Maurer W. Pallor of the optic disc in glaucoma patients with artificial hypertension. Doc Ophthalmol 1984; 57: 203–214
Robert Y, Niesel R, Ehrengruber H. Measurement of the optical density of the optic nerve head. The pallor of the papilla in artificial hypertension. Graefes Arch Clin Exp Ophthalmol 1982; 219: 176–182
Sossi N, Anderson DR. Effect of elevated intraocular pressure on blood flow. Occurrence in cat optic nerve head studied with 125-jodoantipyrine. Arch Ophthalmol 1982; 101: 98–101
Stodtmeister R, Wilder D, Pillunat LE. Angiographie und Okulo-oszillo-dynamographie (unpublished)
Stodtmeister R, Bischof G. Die Beziehung zwischen Oberarm-und Augenblutdruck bei unterschiedlichen Meß-methoden. Klin Mbl Augenheilk 1985; 187: 230
Stodtmeister R, Hornberger M, Höfer M, Gaus W, Pillunat LE, Swobodnik W, Bischof G. Okulo-Oszillodynamographie nach Ulrich und Ulrich: Ergebnisse bei Augengesunden. Klin Mbl Augenheilk (in press)
Thiel R. Glaukom ohne Hochdruck. Ber dtsch ophthal Ges 1930; 48: 133–138
Ulrich WD, Ulrich Ch. Ukulo-oszillodynamographie, ein neues Untersuchungsverfahren zur Bestimmung des Ophthalmikadruckes und zur okulären Pulskurvenanalyse. Klin Mbl Augenheilk 1985; 186: 185–190
Ulrich WD, Ulrich Ch. Oculo-oscillo-dynamography: a diagnostic procedure for recording ocular pulses and measuring retinal and ciliary arterial blood pressures. Ophthalmic Res 1985; 17: 308–314
Ulrich WD, Ulrich CH, Bohne BD, Niederländer C. Relationship between ciliary perfusion pressure and pattern-reversal visual evoked cortical potentials: An Electro-Encephalo-Dynamographic Investigation. Ophthalmic Res 1986; 18: 260–264
Ulrich WD, Ulrich Ch, Bohne BD. Deficient Autoregulation and Lengthening of the Circulation in Glaucoma: An Electro-Encephalo-Dynamographic Investigation. Ophthalmic Res 1986; 18: 253–259
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Pillunat, L.E., Stodtmeister, R., Marquardt, R. et al. Ocular perfusion pressures in different types of glaucoma. Int Ophthalmol 13, 37–42 (1989). https://doi.org/10.1007/BF02028635
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DOI: https://doi.org/10.1007/BF02028635