Abstract
Oxiconazole, a new imidazole derivative, has a broad antifungal spectrum in vitro and in vivo. Adult New Zealand white rabbits were injected intravitreally with doses ranging from 10 to 100 micrograms of this drug. Eyes were evaluated with preoperative and postoperative biomicroscopy and indirect ophthalmoscopy, electroretinography, and light microscopy. From these data, it was determined that an intravitreal injection containing a concentration of up to 100 micrograms per 0.1 milliliter of oxiconazole was nontoxic to the rabbit eye.
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References
Gilbert CM, Novak MA. Successful treatment of post-operative Candida endophthalmitis in an eye with an intraocular lens implant. Am J Ophthalmol 1984; 97: 593–5.
Pettit TH, Olson RJ, Foos RY, Martin WJ. Fungal endophthalmitis following intraocular lens implantation. A surgical epidemic. Arch Ophthalmol 1980; 98: 1025–39.
Jones DB. Therapy of postsurgical fungal endophthalmitis. Trans Am Acad Ophthalmol Otolaryngol 1978; 85: 357–73.
Rowsey, JJ, Newsome DL, Sexton DJ, Harms WH. Endophthalmitis; current approaches. Ophthalmology 1982; 89: 1055–65.
O'Day DM, Head WS, Robinson RD et al. Intraocular penetration of systemically administered antifungal agents. Current Eye Res 1985; 4: 131–4.
Silverman CA, Yoshizumi MO. Ocular toxicity of experimental intravitreal DMSO. J Toxicol Cutan Ocular Toxicol 1983; 2: 193–200.
Salmon JF, Partridge BM, Spalton DJ. Candida endophthalmitis in a heroin addict: A case report. Br J Ophthalmol 1983; 67: 306–309.
Gebhart RJ, Espinel-Ingroff A, Shadomy S. In vitro susceptibility studies with oxiconazole (RO 13-8996). Chemotherapy 1984; 32: 244–7.
Polak. Oxiconazole, a new imidazole derivative. Drug Res 1982; 32: 17–24.
Polak A. Antifungal activity of four antifungal drugs in the cutaneous retention time test. Sabouraudia 1984; 22: 501–3.
Odds FC, Webster CE, Abbott AB. Antifungal relative inhibition factors: Bay 1-9139, bifonazole, butoconazole, isoconazole, itraconazole (R51211), oxiconazole, RO14-4767/002, sulconazole, terconazole and vibunazole (Bay N-7133) compared in vitro with nine established antifungal agents. Antimicrob Agents Chemother 1984; 14: 105–14.
Plempel M, Berg D, Büchel KH, Abbin KD. Test methods for antifungal agents — a critical review. Mykosen 1987; 30: 28–37.
Maurice DM. Injection of drugs into the vitreous body. In: Leopold IH, Burns RP, eds. Symposium on ocular therapy, Vol. 9. New York: Wiley, 1976: 59–72.
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Schulman, J.A., Peyman, G.A., Dietlein, J. et al. Toxicity of intravitreal oxiconazole. Int Ophthalmol 13, 201–203 (1989). https://doi.org/10.1007/BF02028210
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DOI: https://doi.org/10.1007/BF02028210