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Substance P as a potent stimulator of sneeze responses in experimental allergic rhinitis of guinea pigs

  • Allergy and Histamine
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Abstract

Substance P was examined for sneeze-inducing activity and its involvement of sneeze responses in experimental allergic rhinitis. Substance P, dripped into a nostril of guinea pigs, at concentrations of 100 pM and above induced sneezing in a dose-dependent fashion. The activity of substance P was not affected by the previous subcutaneous injections of capsaicin that depleted substance P in nerve fibers. Histamine induced sneezing at concentrations of 30 mM and above and the activity was reduced by capsaicin treatment. The frequency of antigen-induced sneezing was proportional to the substance P content in nasal mucosa of sensitized guinea pigs treated with increasing doses of capsaicin; correlation coefficient 0.91. These results suggest that substance P plays an important role as a stimulator of sneeze responses in experimental allergic rhinitis in guinea pigs.

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Authors and Affiliations

  1. Division of Molecular Pathology, Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Honjo 2-2-1, 860, Kumamoto, Japan

    T. Imamura & T. Kambara

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  1. T. Imamura
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  2. T. Kambara
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Imamura, T., Kambara, T. Substance P as a potent stimulator of sneeze responses in experimental allergic rhinitis of guinea pigs. Agents and Actions 37, 245–249 (1992). https://doi.org/10.1007/BF02028116

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  • DOI: https://doi.org/10.1007/BF02028116

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