Abstract
Histamine (HA) level and its metabolism in adenocarcinoma mammae, spontaneously growing cancer in C3H mice, were examined in relation to the type of tumor, intensity of tumor vascularization and the presence or absence of a secretory function. Histamine concentration being in mammary gland one of the highest among mammalian organs (418 nmol/g) was decreased by 90% in tumor (34 nmol/g). Similarly, histidine decarboxylase (HDC) activity dropped from approximately 7.6 pmol/min/g in normal gland to an undetectable level in adenocarcinoma mammae. Of the two main HA degrading enzymes, namely, diamine oxidase and histamineN-methyl-transferase (HMT), only HMT could be detected in mammary gland, either healthy or neoplastic, and its activity was about 5-fold lower in tumor than in the control tissue (1 nmol/g/min vs. 5.2 nmol/g/min).
The pattern of changes in histaminergic parameters evoked by the tumor was similar irrespective of the morphological type it represented, characteristics of its vascular bed or whether or not it showed secretory activity.
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References
J. Bartholeyns and J. R. Fozard,Role of histamine in tumor development. Trends Pharmacol. Sci.6, 123–125 (1985).
C. Burtin, J. C. Salomon, G. Lespinats, C. Frayssinet, B. Lebel and P. Canu,Increase tissue histamine in tumourbearing mice and rats. Br. J. Cancer43, 684–688 (1981).
A. Faray, G. Lespinats, P. Scheinmann, J. C. Salomon, J. R. Paupe, P. Canu, R. Villet and C. Burtin,Selective increased tissue histamine levels in tumour-bearing rodents. Agents Actions13, 230–233 (1983).
C. Maslinski, D. Kierska, K. Sasiak and B. Adamas,Histamine and its catabolism in tumour-bearing rat and mouse. Agents Actions14, 497–500 (1984).
J. Bartholeyns and M. Bouclier,Involvemeent of histamine in growth of mouse and rat tumours: Antitumoral properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase. Cancer Res.44, 639–645 (1984).
M. Dy and B. Lebel,Skin allografts generate an enhanced production of histamine and histamine-producing cell-stimulating factor (HCSF) by spleen cells in response to T cell mitogens. J. Immunol.130, 2343–2347 (1983).
C. Maslinski and D. Kierska,Histamine in C3H mice carrying spontaneous tumor of mammary gland. Agents Actions33, 192–194 (1991).
R. W. Schayer,Histamine and microcirculation. Life Sci.15, 391–401 (1974).
G. W. Harris,The central nervous system, neurohypophysis and milk ejection. Proc. R. Soc. Biol. (London)149, 336–353 (1958).
J. L. Linzell,Some observations on the contractile tissue of the mammary gland. J. Physiol. (London)130, 257–267 (1955).
A. Czarnomska and H. Szymanska,Kontrola genetyczna myszy laboratoryjnych. III. Analiza czestości wystepowania nowotworów samoistnych, skrobiowicy i zmian skórnych u myszy z 16 szczepów wsobnych. Zwierzeta Lab.22, 113–151 (1985).
F. Squartini,Tumors of the mammary gland. InPathology of Tumours in Laboratory Animals, Vol. II — Tumours of the Mouse. (Ed. V. S. Turusov) pp. 43–90, IARC Scientific Publications No. 23, Lyon, 1979.
T. B. Dunn,Morphology of mammary tumors in mice. InThe Physiopathology of Cancer. (Eds. F. Hamburger and WH. Fishman) pp. 123–148, London Kassel, 1953.
W. A. Fogel,Enzymatic histamine catabolism in vertebrate ontogenesis. A comparative study. Comp. Biochem. Physiol.89C, 355–360 (1988).
T. Watanabe, Y. Taguchi, K. Sasaki, K. Tsuyama and Y. Kitamura,Increase in histidine decarboxylase activity in mouse skin after application of the tumor promoter of tetradeca noylphorbol acetate. Biochem. Biophys. Res. Commun.100, 427–432 (1981).
S. H. Snyder and J. Axelrod,Sex differences and hormonal control of histamine methyltransferase activity. Biochim. Biophys. Acta111, 416–421 (1965).
R. J. Wurtman and J. Axelrod,A sensitive and specific assay for the estimation of monoamine oxidase activity. Biochem. Pharmacol.12, 1439–1441 (1963).
W. A. Fogel, M. Ulatowska, K. Adach and Z. Osinska,A sum of 14 C putrescine metabolites as a measure of DAO activity. Column chromatography assay. Agents Actions16, 99–101 (1985).
M. Garcia-Caballero, E. Neugebauer, F. Rodriguez, J. Nunez de Castro, A. Heredia, E. Oosting and C. Vara-Thorbeck,Changes in histamine synthesis,-tissue content and catabolism in human breast cancer. Agents Actions27, 227–231 (1989).
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Kierska, D., Szymańska, H. & Maslinski, C. Decreased histamine content and metabolism in mammary cancer tissue from C3H mice. Agents and Actions 37, 227–231 (1992). https://doi.org/10.1007/BF02028113
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DOI: https://doi.org/10.1007/BF02028113