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Characterization of aeroallergen-induced dyspnea in unrestrained guinea pigs by bias-flow-ventilated whole body plethysmography

  • Pulmonary Research Group Meeting On Animal Models of Airway Hyperreactivity and Late-Phase Responses
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Abstract

Aeroallergen-induced dyspnea in guinea pigs was associated with an increase in amplitude in the box pressure fluctuations (212%) and pseudo-flow signal (604%) and an 80% decline (from 0.19 to 0.04 s) in relaxation time (the time it takes the box pressure signal to drop from its peak to 1/3 of its peak value). All of these lung dysfunction changes were highly significant (P<0.001). Pyrilamine (1 mg/kg, p.o., −2 h) inhibited dyspnea (ΔP and ΔF) by 50–53%. This technique allows quantitative analysis of allergic dyspnea in conscious, unrestrained guinea pigs.

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References

  1. B. E. Pennock, C. P. Cox, R. M. Rogers, W. A. Cain and J. H. Wells,A noninvasive technique for measurement of changes in specific airway resistance. J. Appl. Physiol.46, 399–406 (1979).

    PubMed  Google Scholar 

  2. K. P. Agrawal,Assessment of airway reactivity in guinea pigs using a non-invasive body plethysmographic technique. Ind. J. Chest Dis. Allied Sci.19, 3–7 (1977).

    Google Scholar 

  3. Y. Alarie, M. Iwasaki and M. Schaper,Whole-body plethysmography in sedentary or exercise conditions to determine pulmonary toxicity, including hypersensitivity induced by airborne toxicants. J. Am. Coll. Tox.9, 407–439 (1990).

    Google Scholar 

  4. N. Chand, K. Nolan, J. Pillar, W. Diamantis, R. D. Sofia and M. Lomask,Aeroallergen-induced dyspnea in freely moving guinea pigs: Quantitative measurement by bias flow ventilated whole body plethysmography. Allergy (in press).

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Authors and Affiliations

  1. Wallace Laboratories, Division of Carter-Wallace Inc., Half Acre Rd., 08512, Cranbury, NJ, USA

    N. Chand, K. Nolan, J. Pillar, W. Diamantis & R. D. Sofia

  2. Buxco Electronics Inc., West Woods Rd., 06069, Sharon, Conn., USA

    M. Zomask

Authors
  1. N. Chand
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  2. K. Nolan
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  3. J. Pillar
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  4. M. Zomask
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  5. W. Diamantis
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  6. R. D. Sofia
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Chand, N., Nolan, K., Pillar, J. et al. Characterization of aeroallergen-induced dyspnea in unrestrained guinea pigs by bias-flow-ventilated whole body plethysmography. Agents and Actions 37, 184–187 (1992). https://doi.org/10.1007/BF02028104

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  • DOI: https://doi.org/10.1007/BF02028104

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