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Structure-activity profile of substituted purines and inflammation in the delayed hypersensitivity skin reaction

  • Immunosuppression and Inflammation
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Abstract

Substituted purines were tested for their effectiveness in inhibiting the delayed hypersensitivity skin reaction (DHSR) caused by tuberculin in the guinea-pig. Among the tested purines were naturally occurring derivatives of guanine and adenine, including cyclic AMP. Based on the structure-activity profile, a class of purines was identified, the members of which were very effective inhibitors of inflammatory aspects of the DHSR and are characterized by a benzyl group in position 9, an amino or alkylamino group in position 6, and various substituents in position 2. This class of 2-substituted-9-benzyladenines was more effective in the DHSR than some antimetabolites, particularly the structurally related mercaptopurines.

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Authors and Affiliations

  1. Department of Biochemical Pharmacology, The Squibb Institute for Medical Research, 08540, Princeton, New Jersey, USA

    R. J. Wojnar, K. A. Losee & R. J. Brittain

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  1. R. J. Wojnar
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  2. K. A. Losee
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  3. R. J. Brittain
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Wojnar, R.J., Losee, K.A. & Brittain, R.J. Structure-activity profile of substituted purines and inflammation in the delayed hypersensitivity skin reaction. Agents and Actions 5, 145–151 (1975). https://doi.org/10.1007/BF02027356

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  • DOI: https://doi.org/10.1007/BF02027356

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