Abstract
A new anti-inflammatory assay is described, utilizing a subcutaneously implanted elongated section of cotton twine to induce granuloma in rats. The cotton twine irritant is easily introduced under the abdominal skin and after seven days a well formed granuloma is established. The procedure works effectively for both steroidal and nonsteroidal anti-inflammatory drug evaluation. Consistency of the cotton twine eliminates individual weighing of each section and uniformity in compactness affords reproducible results.
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Rassaert, C.L., Dipasquale, G. & O'Donoghue, S. The evaluation of cotton twine as a new anti-inflammatory assay. Agents and Actions 5, 128–132 (1975). https://doi.org/10.1007/BF02027353
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DOI: https://doi.org/10.1007/BF02027353