, Volume 46, Issue 2, pp 222–223 | Cite as

N-cadherin detected in the membrane fraction of lens fiber cells

  • H. Maisel
  • P. Atreya
Research Articles


N-cadherin was identified as a glycoprotein present in the fiber cell membranes of frog, chick, bovine, rabbit and human lenses. The molecular size of N-cadherin varies with the species. Homogenization of the chick lens in the presence of Ca2+ resulted in a decrease in the concentration of N-cadherin. This suggests that the lens contains a Ca2+-activated protease which can act on N-cadherin.

Key words

Lens membranes, N-cadherin glycoproteins 


  1. 1.
    Takeichi, M., Trends Genet.3 (1987) 213.Google Scholar
  2. 2.
    Takeichi, M., Nature320 (1986) 447.PubMedGoogle Scholar
  3. 3.
    Volk, T., and Geiger, B., J. Cell Biol.103 (1986) 1441.PubMedGoogle Scholar
  4. 4.
    Heslip, J., Bagchi, M., Zhang, S., Alousi, S., and Maisel, H., Curr. Eye Res.5 (1986) 949.PubMedGoogle Scholar
  5. 5.
    Laemmli, U. K., Nature227 (1970) 680.PubMedGoogle Scholar
  6. 6.
    Crittenden, S. L., Rutishauser, U., and Lilien, J., Proc. natl Acad. Sci. USA85 (1988) 3464.PubMedGoogle Scholar
  7. 7.
    Lo, W. K., Cell Tissue Res.254 (1988) 31.PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag Basel 1990

Authors and Affiliations

  • H. Maisel
    • 1
  • P. Atreya
    • 1
  1. 1.Department of Anatomy/Cell BiologyWayne State University, School of MedicineDetroitUSA

Personalised recommendations