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Maternal vitamin A restriction alters biochemical development of the brain in rats

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Summary

The biochemical development of the fetal brain in relation to maternal vitamin A restriction was studied in rats. The vitamin A status of pregnant rats was varied by supplying low, medium and adequate amounts (6, 40, and 100 μg retinol/day/kg body weight, respectively) of vitamin A during pregnancy and suckling. The maternal vitamin A restriction caused an altered brain development in terms of tissue weight, DNA, RNA and protein levels, and biosynthesis of DNA and protein from [3H]-thymidine and [3H]-leucine, respectively. A dose-dependent effect of maternal vitamin A restriction on the metabolism of DNA, RNA and protein was noticed in the developing fetal brain of rats.

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Authors and Affiliations

  1. Department of Biochemistry, Vallabhbhai Patel Chest Institute, Delhi University, 110007, Delhi, India

    U. K. Misra

  2. Max-Planck Institute for Physiological and Clinical Research, Benekestraße 2, D-6350, Bad Nauheim, Federal Republic of Germany

    H. S. Sharma

Authors
  1. H. S. Sharma
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  2. U. K. Misra
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Sharma, H.S., Misra, U.K. Maternal vitamin A restriction alters biochemical development of the brain in rats. Experientia 46, 208–211 (1990). https://doi.org/10.1007/BF02027317

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  • DOI: https://doi.org/10.1007/BF02027317

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