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, Volume 6, Issue 6, pp 724–727 | Cite as

Smooth muscle sensitization induced by vinblastine

  • J.-P. Famaey
  • J. Fontaine
  • J. Reuse
Immunosuppression and Inflammation Research Reports

Abstract

At the optimal concentration of 10 mg/l, vinblastine increases the submaximal contractions of the isolated guinea-pig ileum induced by the following agonists: acetylcholine, histamine, nicotine, angiotensine, prostaglandins E1 and F (but not serotonine). It also increases the contractions induced by transmural electrical stimulations of the guinea-pig ileum and reverses the inhibitory effect of non-steroidal anti-inflammatory drugs on these electrically-induced contractions.

Keywords

Smooth Muscle Nicotine Histamine Prostaglandin Acetylcholine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • J.-P. Famaey
    • 1
  • J. Fontaine
    • 1
  • J. Reuse
    • 1
  1. 1.Laboratory of Pharmacology, Rheumatology Unit, School of Medicine and Institute of PharmacyUniversity of BrusselsBrusselsBelgium

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