Agents and Actions

, Volume 6, Issue 6, pp 724–727 | Cite as

Smooth muscle sensitization induced by vinblastine

  • J.-P. Famaey
  • J. Fontaine
  • J. Reuse
Immunosuppression and Inflammation Research Reports

Abstract

At the optimal concentration of 10 mg/l, vinblastine increases the submaximal contractions of the isolated guinea-pig ileum induced by the following agonists: acetylcholine, histamine, nicotine, angiotensine, prostaglandins E1 and F (but not serotonine). It also increases the contractions induced by transmural electrical stimulations of the guinea-pig ileum and reverses the inhibitory effect of non-steroidal anti-inflammatory drugs on these electrically-induced contractions.

Keywords

Smooth Muscle Nicotine Histamine Prostaglandin Acetylcholine 

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Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • J.-P. Famaey
    • 1
  • J. Fontaine
    • 1
  • J. Reuse
    • 1
  1. 1.Laboratory of Pharmacology, Rheumatology Unit, School of Medicine and Institute of PharmacyUniversity of BrusselsBrusselsBelgium

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