The Journal of Membrane Biology

, Volume 40, Supplement 1, pp 151–165 | Cite as

The mitochondria-rich cell of frog skin as hormone-sensitive “shunt-path”

  • C. L. Voûte
  • W. Meier
Article

Summary

Further investigations about the role of the mitochondria-rich cell (MR cell) in hormone-mediated transport regulation in the epithelium of frog skin brought the following results: Unlike toad bladder, in frog skin the spontaneous potential difference cannot be reversed when Na transport is blocked. A similar situation is obtained when in addition to transport-blockade, one applies a chemical gradient for chloride to the epithelium. Under these conditions we found that in the intact preparation as well as in the separated epithelium: (i) the reversed current (RC) is linearly related to the number of MR cells; (ii) RC is mainly carried by a passive, transcellular chloride flux inwards and (iii) RC is sensitive to nor-adrenaline (10−7m). The beta-blocker propranolol abolishes this effect.

We propose that the MR cells are the sites of transepithelial shunt-path and that this chloride flux is transcellular. As it is hormone sensitive, it could be an important regulatory instrument for the regulation of overall salt transport (internal shorting).

Keywords

Chloride Human Physiology Propranolol Reversed Current Chemical Gradient 

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Copyright information

© Springer-Verlag New York Inc 1978

Authors and Affiliations

  • C. L. Voûte
    • 1
  • W. Meier
    • 1
  1. 1.The Laboratory of Experimental Nephrology, Department of Medicine-KantonsspitalUniversity of BaselBaselSwitzerland

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