The Journal of Membrane Biology

, Volume 40, Supplement 1, pp 5–14 | Cite as

Physiology of transport regulation

  • Hans H. Ussing
Article

Summary

The regulation of biological transport is discussed on the basis of studies on sodium transport through amphibian skin. The following types of regulation are briefly considered:
  1. 1)

    Hormonal regulation

     
  2. 2)

    Regulation of Na entry by apparent or real saturation of entry path by outside Na

     
  3. 3)

    Regulation of Na transport by changes in resistance to the counter ion (mostly chloride)

     
  4. 4)

    Role of cellular Na concentration which may act both by controlling the passive entry of Na and by influencing the pumping rate.

     
  5. 5)

    Dependence of Na entry upon cell volume. It is shown that a moderate osmotic swelling of ouabain-poisoned skins leads to excessive swelling of the whole epithelium when NaCl is present on the outside. This indicates that cell swelling leads to opening of the Na channels, but it also indicates coupling between the different layers of the epithelium.

     

Keywords

Sodium Chloride Human Physiology Cell Volume Hormonal Regulation 

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Copyright information

© Springer-Verlag New York Inc 1978

Authors and Affiliations

  • Hans H. Ussing
    • 1
  1. 1.Institute of Biological Chemistry AUniversity of CopenhagenCopenhagenDenmark

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