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The topical anti-inflammatory effects of piroxicam in rodents

  • Immunosuppression and Inflammation
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Abstract

Piroxicam is a structurally novel, long-acting anti-inflammatory drug with potent activity following oral administration in animal models of inflammation and in human inflammatory diseases. The present studies, performed in rats, demonstrate that topically applied piroxicam is a potent inhibitor of inflammation induced by either carrageenin or complete Freund's adjuvant. Comparable potencies (ED50 approximately 1–5 mg/kg) were obtained for topically and orally administered piroxicam in these models of inflammation. The potency of topical piroxicam exceeds that of topically applied bufexamac or phenylbutazone in the rat adjuvant arthritis model.

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  1. Department of Pharmacology and Medicinal Chemistry, Pfizer Central Research, 06340, Groton, CT, USA

    David L. Larson & Joseph G. Lombardino

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  1. David L. Larson
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  2. Joseph G. Lombardino
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Larson, D.L., Lombardino, J.G. The topical anti-inflammatory effects of piroxicam in rodents. Agents and Actions 10, 246–251 (1980). https://doi.org/10.1007/BF02025943

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  • DOI: https://doi.org/10.1007/BF02025943

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