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, Volume 10, Issue 3, pp 231–239 | Cite as

Enhanced anti-inflammatory effect and reduced immunogenicity of bovine liver superoxide dismutase by conjugation with homologous albumin

  • K. Wong
  • L. G. Cleland
  • M. J. Poznansky
Immunosuppression and Inflammation


Bovine liver superoxide dismutase (SOD) can be crosslinked to albumin to form soluble conjugates with up to 70% retention of original enzyme activity. These conjugates have markedly prolonged plasma half-times of enzymatic activity (15 h) compared to native SOD (6 min). The conjugates have potent anti-inflammatory effects in vivo and reduced immunogenicity and antigenicity compared to native SOD. These conjugates provide new possibilities for the study of inflammation and its treatment.


Enzymatic Activity Albumin Superoxide Superoxide Dismutase Bovine Liver 


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Copyright information

© Birkhäuser-Verlag 1980

Authors and Affiliations

  • K. Wong
    • 1
    • 2
  • L. G. Cleland
    • 1
    • 2
  • M. J. Poznansky
    • 1
    • 2
  1. 1.Rheumatic Disease Unit, Department of MedicineUniversity of AlbertaEdmontonCanada
  2. 2.Department of PhysiologyUniversity of AlbertaEdmontonCanada

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