Enhanced anti-inflammatory effect and reduced immunogenicity of bovine liver superoxide dismutase by conjugation with homologous albumin
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Bovine liver superoxide dismutase (SOD) can be crosslinked to albumin to form soluble conjugates with up to 70% retention of original enzyme activity. These conjugates have markedly prolonged plasma half-times of enzymatic activity (15 h) compared to native SOD (6 min). The conjugates have potent anti-inflammatory effects in vivo and reduced immunogenicity and antigenicity compared to native SOD. These conjugates provide new possibilities for the study of inflammation and its treatment.
KeywordsEnzymatic Activity Albumin Superoxide Superoxide Dismutase Bovine Liver
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