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, Volume 9, Issue 2, pp 212–216 | Cite as

The pharmacological consequences of the binding of anti-rheumatic drugs to plasma proteins in the treatment of rheumatoid arthritis

  • J. Neil McArthur
Immunosuppression and Inflammation Research Reports

Abstract

Evidence is presented that rheumatoid arthritis is a disease resulting from abnormal protein binding and that anti-rheumatic drugs act by correcting the abnormal binding.

Keywords

Rheumatoid Arthritis Arthritis Plasma Protein Pharmacological Consequence Abnormal Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. [1]
    J.N. McArthur, P.D. Dawkins, M.J.H. Smith andE.B.D. Hamilton,Mode of Action of Anti-Rheumatic Drugs, Brit. Med. J.2, 677–679 (1971).PubMedGoogle Scholar
  2. [2]
    P.S. Hench,The Potential Reversibility of Rheumatoid Arthritis, Ann. Rheum. Dis.8, 90–96 (1949).Google Scholar
  3. [3]
    M.J.H. Smith andP.H. Smith,The Salicylates (John Wiley & Sons, New York, 1966).Google Scholar
  4. [4]
    R.I. Flower,Drugs which Inhibit Prostaglandin Biosynthesis, Pharmac. Reviews26, 33–67 (1974).Google Scholar
  5. [5]
    J.N. McArthur andM.J.H. Smith,The Determination of the Binding of Salicylate to Serum Proteins, J. Pharm. Pharmac.21, 589–594 (1969).Google Scholar
  6. [6]
    J.N. McArthur, P.D. Dawkins andM.J.H. Smith,The Relationship Between Circulating and Tissue Concentrations of Salicylate in the Mouse In Vivo, J. Pharm. Pharmac.22, 801–805 (1970).Google Scholar
  7. [7]
    K. Brune,How Aspirin Might Work: A Pharmaco Kinetic Approach, Agents and Actions4 (4), 230–232 (1974).PubMedGoogle Scholar
  8. [8]
    J.R. Gillette,Overview of Drug-Protein Binding, Ann. N.Y. Acad. Sci.226 (7), 6–17 (1973).PubMedGoogle Scholar
  9. [9]
    I. James,Disease-Altered Drug Action, Drug Therapy6, 113–126 (1976).Google Scholar
  10. [10]
    J.N. McArthur andM.J.H. Smith,Binding of Salicylate to Albumin, Febs Letters1, 332–334 (1968).PubMedGoogle Scholar
  11. [11]
    R.H. McMenamy andJ.L. Oncley,The Specific Binding of l -Tryptophan to Serum Albumin, J. Biol. Chem.233, 1436–1447 (1958).PubMedGoogle Scholar
  12. [12]
    J.N. McArthur andP.D. Dawiins,The Effect of Sodium Salicylate on the Binding of l -Tryptophan to Serum Proteins, J. Pharm. Pharmac.21, 744–750 (1969).Google Scholar
  13. [13]
    J.N. McArthur, P.D. Dawkins andM.J.H. Smith,The Displacement of l -Tryptophan and Dipeptides from Bovine Albumin In Vitro and from Human Plasma In Vivo by Anti-Rheumatic Drugs, J. Pharm. Pharmac.23, 393–398 (1971).Google Scholar
  14. [14]
    P. Lee, M. Watson, J. Webb, J. Anderson andW. Buchanan,Therapeutic Effectiveness of Paracetamol in Rheumatoid Arthritis, Int. J. Clin. Pharmacol.11, 68–75 (1975).Google Scholar
  15. [15]
    M.J.H. Smith, P.D. Dawkins andJ.N. McArthur,The Relation Between Clinical Anti-Inflammatory Activity and the Displacement of l -Tryptophan and a Dipeptide from Human Serum In Vitro, J. Pharm. Pharmac.23, 451 (1971).Google Scholar
  16. [16]
    Research Subcommittee of The Empire Rheumatism Council,Gold Therapy in Rheumatoid Arthritis. Ann. Rheum. Dis.20, 315–333 (1961).Google Scholar
  17. [17]
    M. Aylward, J. Maddock, R. Wheeldon andR.J. Parker,A Study on the Influence of Various Anti-Rheumatic Drug Regimens on Acute-Phase Proteins Plasma Tryptophan and Erythrocyte Sedimentation Rate in Rheumatoid Arthritis, Rheum. and Rehab.14, 104–113 (1975).Google Scholar
  18. [18]
    J.S. Lawrence,Studies with Radioactive Gold, Ann. Rheum. Dis.20, 341–352 (1961).PubMedGoogle Scholar
  19. [19]
    R.J. Ward, C.J. Danpure andD.A. Fyfe,Determination of Gold in Plasma and Plasma Fractions by Atomic Absorption Spectrophotometry and by Neutron Activation Analysis, Clin. Chim. Acta81, 87–97 (1977).PubMedGoogle Scholar
  20. [20]
    K. Diem andC. Lentner (Eds.),Documenta Geigy Scientific Tables, Seventh Edition (J.R. Geigy, Switzerland, 1970).Google Scholar
  21. [21]
    J.N. McArthur, M.J.H. Smith andE.B.D. Hamilton,Protein-Bound Peptides in Human Serum, Brit. Med. J.4, 230 (1971).Google Scholar
  22. [22]
    J.N. McArthur, M.J.H. Smith andP.C. Freeman,Anti-Inflammatory Substance in Human Serum, J. Pharm. Pharmac.24, 669–671 (1972).Google Scholar
  23. [23]
    P.N.C. Elliott, A.W. Ford-Hutchison, D.J. Harford, M.Y. Insley, M.J.H. Smith andE.A. Sturgess,Anti-Inflammatory Activity in Human Plasma, J. Pharm. Pharmac.25, 408 (1973).Google Scholar
  24. [24]
    M. Aylward andJ. Maddock,Total and Free Plasma Tryptophan Concentrations in Rheumatoid Diseases J. Pharm. Pharmac.25, 570–572 (1973).Google Scholar
  25. [25]
    M. Aylward andJ. Maddock,Plasma Tryptophan Levels in Depression, Lancet1, 936 (1973).Google Scholar
  26. [26]
    A.D. Broadhurst,Tryptophan and Rheumatic Diseases, Brit. Med. J.2, 456 (1977).Google Scholar
  27. [27]
    Rheumatoid Arthritis, JAMA224, 687–700 (1973).Google Scholar
  28. [28]
    P.D. Dawkins, J.N. McArthur andM.J.H. Smith,The Effect of Sodium Salicylate on the Binding of Long-Chain Fatty Acids to Plasma Proteins, J. Pharm. Pharmac.22, 405–410 (1970).Google Scholar
  29. [29]
    W.E. Klopfenstein,Regulation of Albumin Bound Tryptophan, Nature250, 444 (1974).PubMedGoogle Scholar
  30. [30]
    J.N. McArthur,Possible Relationship Between pH of Plasma and Rheumatoid Arthritis, Life Sciences18, 947–952 (1976).PubMedGoogle Scholar
  31. [31]
    C.W. Denko, D.B. Purser andR.M. Johnson,Amino Acid Composition of Serum Albumin in Normal Individuals and Patients with Rheumatoid Arthritis, Clin. Chem.16, 54–57 (1970).PubMedGoogle Scholar
  32. [32]
    J.N. McArthur,Rheumatoid Arthritis and Albumin Binding, J. Rheumatol.1, 241–246 (1974).PubMedGoogle Scholar
  33. [33]
    M. Thompson andE.G.L. Bywaters,Unilateral Rheumatoid Arthritis Following Hemiplegia, Ann. Rheum. Dis.21, 370–377 (1962).PubMedGoogle Scholar
  34. [34]
    I. Yaghmai, S.M. Rooholamini andH.F. Faunce,Unilateral Rheumatoid Arthritis: Protective Effect of Neurologic Deficits, Am. J. Roentgenol.128, 299–301 (1977).Google Scholar
  35. [35]
    J.R. Vane,Mode of Action of Aspirin, J. Allergy Clin. Immun.58 691–712 (1976).PubMedGoogle Scholar
  36. [36]
    D.A. Persons andJ.T. Sharp,The Etiology of Rheumatoid Arthritis, Bull. Rheum. Dis.27, 888–893 (1976–77).Google Scholar
  37. [37]
    M. Aylward andJ. Maddock,Tryptophan Displacement from Human Serum Albumin In Vitro: A New Assay for Screening Drugs for Potential Anti-Inflammatory Activity, Int. Res. Commun. System2, 1143 (1974).Google Scholar

Copyright information

© Birkhäuser-Verlag 1979

Authors and Affiliations

  • J. Neil McArthur
    • 1
  1. 1.Orthopaedic & Arthritic HospitalTorontoCanada

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