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Anti-inflammatory action following liver damage in the rat

  • Immunosuppression and Inflammation
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Abstract

A high molecular weight protein fraction, obtained by column chromatography of saline extracts of the livers of rats that had previously been treated with dimethylnitrosamine, was found to have anti-inflammatory activity against carrageenin induced inflammation in the rat. Evidence was presented that the anti-inflammatory activity may be due to a protein fragment produced by proteolysis of a larger molecule.

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References

  1. P.S. Hench, Proc. Mayo Clin.8, 430 (1933).

    Google Scholar 

  2. F. Gardner, A. Stewart andF.O. MacCallum, Brit. Med. J.2, 677 (1945).

    Google Scholar 

  3. R.S. Pinals, Ann. Rheum. Dis.32, 471 (1973).

    PubMed  Google Scholar 

  4. M.E.J. Billingham, A.H. Gordon andB.V. Robinson, Nature New Biology231, 26 (1971).

    PubMed  Google Scholar 

  5. D.A. Lewis, R. Best andJ. Bird, J. Pharm. Pharmac.29, 113 (1977).

    Google Scholar 

  6. C.A. Winter, E.A. Risley andG.W. Russ, Proc. Soc. exp. Biol. Med.111, 544 (1962).

    PubMed  Google Scholar 

  7. H. Rinderknecht, M.C. Geokas, P. Silverman, Y. Lillard andB.J. Haverback, Clin. chim. Acta19, 327 (1968).

    PubMed  Google Scholar 

  8. A.A. Dietz, H.M. Rubenstein andL. Hodges, Clin. Chem.20, 396 (1974).

    PubMed  Google Scholar 

  9. P.O. Ganrot, Clin. Chim. Acta14, 493 (1966).

    Google Scholar 

  10. A.G. Gornall, C.J. Bardawill andM.M. David, J. Biol. Chem.177, 751 (1949).

    Google Scholar 

  11. D.A. Lewis, R.B. Capstick andR. Best, Biochem. Pharmac.25, 1435 (1976).

    Google Scholar 

  12. M.E.J. Billingham andB.V. Robinson, Br. J. Pharmac.44, 317 (1972).

    Google Scholar 

  13. D.C. Atkinson andR. Hicks, Br. J. Pharmac.53, 85 (1975).

    Google Scholar 

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Authors and Affiliations

  1. Pharmacological Laboratories, Department of Pharmacy, The University of Aston in Birmingham, B4 7ET, Birmingham, UK

    D. A. Lewis, D. P. Parrott, J. Bird & R. Best

Authors
  1. D. A. Lewis
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  2. D. P. Parrott
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  3. J. Bird
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  4. R. Best
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Lewis, D.A., Parrott, D.P., Bird, J. et al. Anti-inflammatory action following liver damage in the rat. Agents and Actions 9, 201–204 (1979). https://doi.org/10.1007/BF02024735

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  • DOI: https://doi.org/10.1007/BF02024735

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