Skip to main content

Inhibition of pepsin secretion by metiamide and atropine in the conscious rat

Agents and Actions volume 9, pages 163–167 (1979)Cite this article

Abstract

The inhibition of pepsin secretion by metiamide and atropine has been studied in the gastric fistula rat and the Heidenhain pouch rat. A comparison of the effectiveness of metiamide and atropine in inhibiting pepsin secretion was made by using doses of the antagonists which produced a similar level of inhibition of acid secretion. In the gastric fistula rat both atropine and metiamide inhibited the basal pepsin output, but atropine was more effective than metiamide in this respect. In the Heidenhain pouch rat a large dose of metiamide which inhibited bethanechol-stimulated acid secretion had no significant effect on the corresponding output of pepsin. In this preparation atropine inhibited both acid and pepsin secretion. Possible reasons for these differences in the two preparations are discussed.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  1. R.W. Brimblecombe andM.E. Parsons,Histamine H 2 -Receptor Antagonists, in:Pharmacological and Biochemical Properties of Drug Substances (Ed. M.E. Goldberg; American Pharmaceutical Association, Washington, D.C., 1977) pp. 329–352.

    Google Scholar 

  2. R. Gibson, B.I. Hirschowitz andG. Hutchison,Actions of Metiamide, an H 2 -Histamine Receptor Antagonist, on Gastric H + and Pepsin Secretion in Dogs, Gastroenterology67, 93–99 (1974).

    PubMed  Google Scholar 

  3. B.I. Hirschowitz andG. Hutchison,Evidence for a Histamine H 2 -Receptor that Inhibits Pepsin Secretion in the Dog, Am. J. Physiol.233, E225–228 (1977).

    PubMed  Google Scholar 

  4. D.F. Magee,Metiamide: An Antagonist of Histamine-Stimulated Gastric Acid Secretion, Ann. Surg.182, 627–629 (1975).

    PubMed  Google Scholar 

  5. S.J. Konturek, T. Radecki, T. Demitrescu andA. Dembinski,Comparison of Effects of Metiamide and Atropine on Gastric and Pancreatic Secretion and Peptic Ulcer Formation in Cat, Digestion10, 267–281 (1974).

    PubMed  Google Scholar 

  6. M. Albinus, E.L. Blair, B.H. Hirst, J.D. Reed, A.V. Schally andB. Shaw,The Effects of Somatostatin and Metiamide on Tachyphalaxis of Pentagastrin Stimulated Gastric Acid and Pepsin Secretion in the Conscious Cat, J. Physiol. Lond.266, 801–817 (1977).

    PubMed  Google Scholar 

  7. S.J. Konturek, J. Biernat andJ. Oleksy,Effect of Metiamide, a Histamine H 2 -Receptor Antagonist, on Gastric Responses to histamine, Pentagastrin, Insulin and Peptone Meal in Man, Am. J. dig. Dis.19, 609–616 (1974).

    PubMed  Google Scholar 

  8. D.C. Carter, J.A.H. Forrest, R.A. Logan, I. Ansell, G. Lidgard, R.C. Heading andD.J.C. Shearman,Effect of the Histamine H 2 -Receptor Antagonist, Cimetidine, on Gastric Secretion and Serum Gastrin During Insulin Infusion in Man, Scand. J. Gastroenterol.11, 565–570 (1976).

    PubMed  Google Scholar 

  9. I. Johansson, L. Lundell andS.E. Svensson,Inhibition of Gastric Secretion by Atropine in Conscious Rats, J. Physiol. Lond.217, 723–736 (1971).

    PubMed  Google Scholar 

  10. K.T. Bunce andM.E. Parsons,The Effect of Hexamethonium on Gastric Acid Secretion in the Conscious Rat, Agents and Actions7, 507–511 (1977).

    PubMed  Google Scholar 

  11. A. Lane, A.C. Ivy andE.K. Ivy,Response of the Chronic Gastric Fistula Rat to Histamine, Am. J. Physiol.190, 221–228 (1957).

    PubMed  Google Scholar 

  12. R.S. Alphin andT.M. Lin,Preparation of Chronic Denervated Gastric Pouches in the Rat, Am. J. Physiol.197, 257–259 (1959).

    PubMed  Google Scholar 

  13. M.M. Vatier, A.M. Cheret andS. Bonfils,Le dosage automatique de l'activité protéolytique du suc gastrique. Biol. Gastroenterol.1, 15–29 (1968).

    Google Scholar 

  14. I. Johansson, L. Lundell, E. Rosengren andS.E. Svensson,Gastric Secretion and its Facilitation as Related to Gastric Mucosal Histamine, J. Physiol. Lond.226, 431–452 (1972).

    PubMed  Google Scholar 

  15. L. Lundell,Elucidation by a H 2 -Receptor Antagonist of the Significance of Mucosal Histamine Mobilisation in Exciting Acid Secretion, J. Physiol. Lond.244, 365–383 (1975).

    PubMed  Google Scholar 

  16. P.O. Schwille, G. Lang andP. Hofmann,Rat Gastric Secretion and Mucosal Blood Flow During Restraint Stress. Effect of a Low Dose Metiamide, Res. exp. Med.171, 205–210 (1977).

    Google Scholar 

  17. R. Håkanson andG. Liedberg,Mechanism of Activation of Rat Stomach Histidine Decarboxylase After Vagal Denervation, Eur. J. Pharmac.16, 78–89 (1971).

    Google Scholar 

  18. K. Kowalewski,Effect of Vagotomy and/or Antrectomy on Gastric Secretion Stimulated by Intravenous Infusion of Bethanechol Chloride. Study on Rats with Gastric Fistula, Am. J. dig. Dis.16, 19–26 (1971).

    PubMed  Google Scholar 

  19. A.R. Hedges andM.E. Parsons,The Effect of Anaesthesia on the Inhibition of Pentagastrin-Evoked Gastric Acid Secretion Induced by Atropine in the Rat. J. Physiol. Lond.267, 181–194 (1977).

    PubMed  Google Scholar 

  20. I. Szelenyi andK. Thiemer,Influence of Metiamide and Atropine on Pepsinogen Secretion in the Conscious Rat, Experientia33, 1620–1621 (1977).

    PubMed  Google Scholar 

  21. H.D. Becker, D.D. Reeder andJ.C. Thompson,The Effect of Changes in Antral pH on the Basal Release of Gastrin, Proc. Soc. exp. Biol. Med.143, 238–240 (1973).

    PubMed  Google Scholar 

  22. L. Sjödin andG. Nilsson,Plasma Gastrin Levels and Gastric Acid Secretion in Dogs During Administration of Urecholine, Scand. J. Gastroenterol.9, 747–750 (1974).

    PubMed  Google Scholar 

  23. R. Håkanson, J. Hedenbro, G. Liedberg, H.A. El Munshid andJ.F. Rehfeld,Gastrin: Obligatory Intermediate in the Post-Prandial Mobilisation of Gastric Histamine in the Rat. Experientia33, 1541–1543 (1977).

    PubMed  Google Scholar 

  24. K.T. Bunce andM.E. Parsons,Inhibition by Metiamide of Secretagogue-Induced Gastric Acid Secretion in the Conscious Heidenhain Pouch Rat, J. Physiol. Lond.285, 49–57 (1978).

    PubMed  Google Scholar 

  25. K.G. Dritsas andK. Kowalewski,The Mechanism of Pepsin Secretion in the Isolated Perfused Canine Stomach. Can. J. Surg.11, 85–92 (1968).

    PubMed  Google Scholar 

  26. L.R. Johnson,Regulation of Pepsin Secretion by Topical Acid in the Stomach, Am. J. Physiol.223, 847–850 (1972).

    PubMed  Google Scholar 

  27. T.E. Bynum andL.R. Johnson, Stimulation of Human Pepsin Output by Topical Hydrochloric Acid, Am. J. dig. Dis.20, 607–612 (1975).

    PubMed  Google Scholar 

Download references

Author information

Affiliations

  1. The Research Institute, Smith Kline & French Laboratories Ltd., Welwyn Garden City, Hertfordshire, England

    K. T. Bunce, M. E. Parsons & F. R. Matheson

Authors
  1. K. T. Bunce
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. E. Parsons
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. R. Matheson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bunce, K.T., Parsons, M.E. & Matheson, F.R. Inhibition of pepsin secretion by metiamide and atropine in the conscious rat. Agents and Actions 9, 163–167 (1979). https://doi.org/10.1007/BF02024728

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02024728

Keywords

  • Atropine
  • Large Dose
  • Acid Secretion
  • Gastric Fistula
  • Pepsin Secretion