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Liberation of histamine by compound 48/80, tolazoline, betahistine and burimamide from isolated spontaneously beating guinea pig and rabbit atrial pairs

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Abstract

Tolazoline, betahistine, burimamide and compound 48/80 release histamine from isolated guinea pig atria resulting in histamine concentrations that will stimulate H2-receptors. Tolazoline, burimamide and 48/80 also release histamine from rabbit atria but do not result in histamine concentrations that will stimulate either H1- or H2-receptors. However, betahistine (which does not release histamine from rabbit atria) and tolazoline stimulate the rabbit atrial chronotropic response by releasing catecholamines.

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References

  1. M.A. Beaven,Histamine, New Engl. J. Med.294 (6), 320–325 (1976).

    PubMed  Google Scholar 

  2. J.W. Black, W.A.M. Duncan, C.J. Durant, C.R. Ganellin andE.M. Parsons,Definition and Antagonism of Histamine H 2 -Receptors, Nature (Lond.)236, 385–390 (1972).

    Google Scholar 

  3. P. Constantinides,Mast Cells and Susceptibility to Experimental Atherosclerosis, Science117, 505–506 (1953).

    PubMed  Google Scholar 

  4. B.P. Curwain, P. Holton andJ. Spencer,The Effect of Betahistine on Gastric Acid Secretion and Mucosal Blood Flow in Conscious Dogs, Brit. J. Pharmacol.46, 351–354 (1972).

    Google Scholar 

  5. D.W. Harris, J.R. Smy, J.D. Reed andC.W. Venables,The Effects of Burimamide and Metiamide on Basal Gastric Function in the Cat, Brit. J. Pharmacol.53, 293–297 (1975).

    Google Scholar 

  6. M.J. Hughes,A Nonhistaminic Response of Rabbit Atria to Betahistine, J. Clin. Pharm.17 (1), 91–92 (1977).

    Google Scholar 

  7. M.J. Hughes andI.A. Coret,On Specificity of Histamine Receptors in the Heart, Am. J. Physiol.223, 1257–1262 (1972).

    PubMed  Google Scholar 

  8. M.J. Hughes andL.J. O'Brien,Liberation of Endogenous Compounds by Tolazoline, Agents and Actions7 (2), 225–230 (1977).

    PubMed  Google Scholar 

  9. T.E. Hunt, E.A. Hunt andD. Curry,Basophil Leucocytes and Mast Cells in the Rabbit Before and After Intravenous Injection of Compound 48/80, Anat. Rec.140, 123–129 (1961).

    PubMed  Google Scholar 

  10. H. Iizuka, K. Adachi, K.M. Halprin andV. Levine,Epidermal Adenylate Cyclase: Stimulation of the Histamine (H 2 ) Receptor by Tolazoline, J. Invest. Dermatol.69, 442–445 (1977).

    PubMed  Google Scholar 

  11. J.H. McNeill andS.C. Verma,Blockade by Burimamide of the Effects of Histamine and Histamine Analogs on Cardiac Contractility, Phosphorylase Activation and Cyclic Adenosine Monophosphate, J. Pharmac. exp. Ther.188, 180–188 (1974).

    Google Scholar 

  12. J.H. McNeill andS.C. Verma,Histamine Receptors in Rabbit Heart, Proc. West Pharmacol. Soc.21, 99–101 (1978).

    PubMed  Google Scholar 

  13. W. Lorenz, L. Benesch, H. Barth, E. Matejka, R. Meyer, J. Kusche, M. Hutzel andE. Werle,Fluorometric Assay of Histamine in Tissues and Body Fluids: Choice of the Purification Procedure and Identification in the Nanogram Range, Z. Anal. Chem.252, 94–98 (1970).

    Google Scholar 

  14. W. Lorenz, E. Matejka, A. Schmal, W. Seidel, H.-J. Reimann, R. Uhlig andG. Mann,A Phylogenetic Study on the Occurrence and Distribution of Histamine in the Gastro-Intestinal Tract and Other Tissues of Man and Various Animals, Comp. gen. Pharmac.4, 229–250 (1973).

    Google Scholar 

  15. W. Lorenz, H.-J. Reimann, H. Barth, J. Kusche, R. Meyer, A. Doenicke andM. Hutzel,A Sensitive and Specific Method for the Determination of Histamine in Human Whole Blood and Plasma, Hoppe-Seyler's Z. Physiol. Chem.353, 911–920 (1972).

    PubMed  Google Scholar 

  16. P.F. Mannaioni andF. Moroni,Uptake, Disposition and Metabolism of Histamine in Isolated Heart Preparations, Brit. J. Pharmac.49, 457–465 (1973).

    Google Scholar 

  17. D.M. Martinez,The Effect of Serc (Betahistine Hydrochloride) on the Circulation of the Inner Ear in Experimental Animals, Acta Otolaryng. Suppl.305, 29–47 (1972).

    Google Scholar 

  18. J.L. Mongar andH.O. Schild,A Comparison of the Effects of Anaphylactic Shock and of Chemical Histimine Releasers, J. Physiol. (Lond.)118, 461–478 (1952).

    Google Scholar 

  19. A.M. Rothschild,Histamine Release by Basic Compounds, in:Handbook of Experimental Pharmacology, vol. 18 (Springer-Verlag, New York, 1966), pp. 8–30.

    Google Scholar 

  20. J. Sanders, D.D. Miller andP.N. Patil,Alpha Adrenergic and Histaminergic Effects of Tolazoline-like Imidazolines, J. Pharmac. exp. Ther.195, 362–371 (1975).

    Google Scholar 

  21. H. Selye,The Mast Cells (Butterworth Inc., Washington, 1965), pp. 125–131.

    Google Scholar 

  22. S.C. Verma andJ.H. McNeill,Comparison of the Effects of Histamine and Tolazoline on the Inotropic, Chronotropic and Cyclic AMP Producing Effects in the Guinea Pig Heart, Proc. West. Pharmacol. Soc.20, 409–444 (1977).

    PubMed  Google Scholar 

  23. S.C. Verma andJ.H. McNeill,Investigations into the Cardiac Effects of Tolazoline in Guinea Pig Atria and Ventricular Strips, Agents and Actions7 (2), 191–197 (1977).

    PubMed  Google Scholar 

  24. I. Weinryb andI.M. Michel,Comparison of the Effects of Histamine and Tolazoline on Adenylate Cyclase Activity from Guinea Pig Heart, J. Med. Chem.18, 23–26 (1975).

    PubMed  Google Scholar 

  25. T.O. Yellin, J.W. Sperow andS.H. Buck,Antagonism of Tolazoline by Histamine H 2 -Receptor Blockers, Nature253, 561–563 (1975).

    PubMed  Google Scholar 

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  1. Department of Physiology, Texas Tech University School of Medicine, 79430, Lubbock, TX, USA

    K. E. Light & M. J. Hughes

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  1. K. E. Light
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  2. M. J. Hughes
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Light, K.E., Hughes, M.J. Liberation of histamine by compound 48/80, tolazoline, betahistine and burimamide from isolated spontaneously beating guinea pig and rabbit atrial pairs. Agents and Actions 9, 141–147 (1979). https://doi.org/10.1007/BF02024725

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  • DOI: https://doi.org/10.1007/BF02024725

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